The objective of the research is to design and evaluate bio compounds Berberis aristata (BCBA) compressed tablets in psoriasis treatment. BCBA dose 300 mg was into by employing microcrystalline cellulose (MCC) sodium starch glycolate (SSG) as superdisintegrant necessary excipients direct compression method. fourier transform infrared (FTIR) results depicts no incompatibility among drug excipien...

We have developed a novel nonviral interleukin 2 (IL-2) gene therapy that demonstrates significant treatment-specific, antitumor efficacy in combination with subtotal surgical resection in a head and neck cancer murine model. Treatment of established head and neck tumors in immunocompetent mice was performed via direct injection with a cationic liposome composed of DOTMA and cholesterol formula...

analysis and prediction of structural response to static or dynamic loading requires prediction of concrete response tovariable load histories. the constitutive equations for the mechanical behavior of concrete capable of seeing damage effects or crack growth procedure under loading/unloading/reloading was developed upon micro-plane framework. the proposed damage formulation has been built on t...

Field experiments were conducted in the rice fields of Malaysian Agricultural Research and Development Institute 2018 2019, to determine efficacy two commercial premix herbicides consisting imazapic imazapyr at 70:30 (formulation 1) 30:70 2) applied singly or sequence for control weedy other weeds. Formulation 1 was as PRE 0 1-leaf stage while formulation 2 POST 3 4-leaf rice. 150 g ai ha-1 wit...

Treating risk as a “currency” has proven to be key in systematically optimizing the design of spacecraft systems. This idea has been applied in the design of individual components of spacecraft systems, and in the end-to-end design of such systems. The process, called “Defect Detection and Prevention” (DDP), its tool support, and applications, are described in [1]. The process can be summarized...

In this paper, we propose an eÆcient approach for unsupervised audio stream segmentation and clustering via the Bayesian Information Criterion (BIC). The proposed method extends an earlier formulation by Chen and Gopalakrishnan[1]. In our segmentation formulation, Hotelling's T -Statistic is used to pre-select candidate segmentation boundaries followed by BIC to make the segmentation decision. ...

The aim of the present work is to design an oral time release tablet by press coating method to achieve a distinct predetermined lag time. In this study Metoprolol tartrate was selected as the model drug. The outer shell was formulated with different weight ratios of Hydroxy propyl methyl cellulose K100M and Ethyl cellulose to achieve a release profile with pre determined lag time. The lag time...

This paper presents a stochastic nonlinear model predictive control technique for discrete-time uncertain nonlinear systems with particular focus on the batch polymerization reactor application. We consider a nonlinear dynamical system subject to chance constraints (i.e. need to be satisfied probabilistically up to a pre-assigned level). This formulation leads to a finite-horizon chance-constra...

We present a new approach to the covariant canonical formulation of EinsteinCartan gravity that preserves the full Lorentz group as the local gauge group. The method exploits lessons learned from gravity in 2+1 dimensions regarding the relation between gravity and a general gauge theory. The dynamical variables are simply the frame field and the spin-connection pulled-back to the hypersurface, ...

This paper addresses the issue of employing space-time adaptive processing (STAP) prior to doppler filtering in radar systems. When STAP beamformer processing is applied to spatial/temporal samples that include successive radar pulses, the adaptive weights can cause modulation (spreading) of the desired target doppler. In this paper, a linearly constrained adaptive beamformer is proposed that e...