Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant, can lead to disease. During mouse development, the genome-wide epigenetic states of pre-implantation embryos and primordial germ cells (PGCs) undergo extensive reprogramming. An improved understanding of the epigenetic reprogramming mechanisms that occur in these cells should provide important new ...

Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This rev...

BACKGROUND As the number of transcatheter aortic valve implantation (TAVI) procedures is constantly increasing, it is important to consider common complications, such as pacemaker (PM) implantation, and their specific risk factors. AIMS Echocardiographic, computed tomography and electrocardiographic data were analysed to determine the predicting factors, if any, associated with PM implantatio...

The mouse embryo generates multiple cell lineages, as well as its future body axes in the early phase of its development. The early cell fate decisions lead to the generation of three lineages in the pre-implantation embryo: the epiblast, the primitive endoderm and the trophectoderm. Shortly after implantation, the anterior-posterior axis is firmly established. Recent studies have provided a be...

background: the aim of this study was to investigate in vivo biocompatibility of resilon, compared with gutta-percha, at short and long-term following implantation in a rat subcutaneous implantation model. materials and methods: male wistar rats were implanted subcutaneously with either resilon or gutta-percha or were sham controls. tissues were harvested at 8 days or 60 days after implantation...

First revealed in cancer studies, HURP (hepatoma up-regulated protein) is a cell cycle-associated gene with elevated expression in the G(2)/M phase. Cell culture studies have revealed that HURP is an essential factor required for spindle formation and chromosome congression during mitosis. However, the function of HURP in an in vivo context has not been explored. We generated a Hurp knock-out (...

BACKGROUND Studies on health-related quality of life (HRQoL) of patients awaiting pacemaker (PM) implantation are scarce, or executed in specific patient subgroups (regarding age or specific cardiac rhythm disorders). The purpose of this study was to systematically assess the HRQoL in a large unselected cohort of patients with a conventional indication for PM therapy. METHODS Pre-PM implantat...

Extracellular matrix (ECM) is widely used as an inductive biological scaffold to repair soft tissue after injury by promoting functional site-appropriate remodeling of the implanted material. However, there is a lack of non-invasive analysis methods to monitor the remodeling characteristics of the ECM material after implantation and its biodegradation over time. We describe the use of diamagnet...

Dual antiplatelet therapy is the mainstay of antiplatelet treatment in percutaneous coronary interventions (PCIs) with stent implantation, as well as in acute coronary syndromes (ACS) with and without ST segment elevation. 3 In ACS, dual antiplatelet therapy has been shown to reduce the risk of death and myocardial infarction (MI), both at the initial phase and in the long term. In the setting ...

PURPOSE To present a case of combined procedure heterotopic autokeratoplasty and ECCE with posterior chamber intraocular lens (IOL) implantation, to demonstrate the novel use an RGP as safe, cost-effective alternative temporary keratoprosthesis. REPORT OF CASE A 65/F presented blindness, OS from glaucoma but clear cornea, corneal decompensation cataract in OD good visual potential. Heterotopic ...