BACKGROUND Oxaliplatin is an integral component of colorectal cancer treatment, but its use is limited by neurotoxicity. The Combined Oxaliplatin Neurotoxicity Prevention Trial (CONcePT) tested intermittent oxaliplatin (IO) administration and the use of concurrent calcium and magnesium salts (Ca/Mg), two modifications intended to reduce neurotoxicity and extend the duration of treatment. PATI...

BACKGROUND  Immune response to quadrivalent human papillomavirus (HPV) vaccine delivered at 0, 2, and 6 months in young adolescent females plateaus around 24 months after immunization. Antibody levels >24 months postvaccination using extended dosing schedules is unknown. METHODS  We conducted a follow-up immunogenicity study of adolescent girls in Vietnam who participated in a noninferiority ...

Using a footshock elicited aggression paradigm, aggressive responses were scored in normal and in septal-lesioned adult male Wistar rats. Septal lesions were made electrolytically to include the medial and lateral septal nuclei. The lesion was confirmed by behavioral criteria (septal aggression) and post-mortem histology. The aggressive response types (threat, attack) of the septal animals were...

In most practical environments, scheduling is an ongoing reactive process where evolving and changing circumstances continually force reconsideration and revision of pre-established plans. Scheduling research has traditionally ignored this \process view" of the problem, focusing instead on optimization of performance under idealized assumptions of environmental stability and solution executabil...

Instruction scheduling is one of the most important code optimizations because of its role in increasing processor utilization. Instruction scheduling reorders instructions to minimize pipeline stalls while preserving program semantics. For realistic processor models, this problem is NP-hard, and numerous heuristic and optimal (enumerative) techniques have been proposed. Heuristics can sometime...

OBJECTIVE Assessment of the safety and efficacy of a 10-day melarsoprol schedule in second stage T.b. rhodesiense patients and the effect of suramin-pretreatment on the incidence of encephalopathic syndrome (ES) during melarsoprol therapy. DESIGN Sequential conduct of a proof-of-concept trial (n = 60) and a utilization study (n = 78) using historic controls as comparator. SETTING Two trial ...

This study discusses problems and facilities in pre-natal and post-natal conditions of rural women at Palosi Peshawar, focusing on the various components of pre and post-natal conditions and facilities available in the area. The researcher selected 30 beneficiaries through purposive sampling technique. Questionnaire and interview schedule were used as the tools of data collection. Data was anal...

Off-line scheduling and fixed priority scheduling (FPS) are often considered as complementing and incompatible paradigms. A number of industrial applications demand temporal properties (predictability, jitter constraints, end-to-end deadlines, etc.) that are typically achieved by using off-line scheduling. The rigid off-line scheduling schemes used, however, do not provide for flexibility. On t...

s for talks on Workshop Wednesday, August 13 9:00 – 9:45 Kashayar Pakdaman, ISC PIF Paris 9:45 – 10:30 Carlos Braumann, Department of Mathematics and CIMA (Centro de Investigação em Matemática e Aplicações), Universidade de Évora, Portugal Stochastic differential equation models for population and individual growth and for harvesting in randomly varying environments The growth of a population l...

s to follow (if desired) in alphabetical order by last name of speaker. Name of 2013 5-day Workshop Date of 2013 5-day Workshop