The orbitofrontal cortex (OFC) has been anatomically divided into a number of subregions along its medial–lateral axis, which behavioral research suggests have distinct functions. Recently, evidence emerged suggesting functional diversity is also present the anterior–posterior axis rodent OFC. However, patterns anatomical connections that underlie these differences not well characterized. Here,...

• Post-weaning/adolescent social isolation increased ?FosB in the cortex and hippocampus of adult mice. FosB was also isolated females. Short-term stress has persistent effects on brain that depend sex. Social is a growing public health concern across lifespan. Specifically, early life, during critical periods development, increases risk psychiatric disorders later life. Previous studies models...

The clinical presentation of schizophrenia involves a variety of symptoms, which in many cases include hallucinations and delusions. Experimentally revealed alterations in both pre-pulse inhibition (PPI) and latent inhibition (LI) are also apparent in individuals afflicted with this disorder. Many have speculated that altered synaptic connections are, in part, responsible for this subset of beh...