BACKGROUND Premature ovarian failure and infertility following chemotherapy in early breast cancer (EBC) are major concerns for young women. The role of gonadotrophin-releasing hormone (GnRH) agonists with chemotherapy in EBC in reducing the incidence of chemotherapy-induced early menopause remains uncertain, and long-term data on the recovery of fertility are sparse. We report an audit of our ...

OBJECTIVE To determine the frequency and causes of preterm ovarian failure (menopause before 40 years of age) and early menopause (menopause between 40 and 45 years). DESIGN Cross sectional study. SETTING Menopause clinics in Italy. POPULATION Women attending menopause clinics in Italy. METHODS Between 1997 and 1999 we conducted a large cross sectional study on the characteristics of wo...

OBJECTIVE To investigate the incidence of ovarian failure after pulse cyclophosphamide treatment in systemic lupus erythematosus (SLE) and to compare this with two control groups: SLE patients treated with azathioprine, and a healthy age matched population. METHODS All women patients with SLE treated with pulse cyclophosphamide in our department were identified and questioned concerning menst...

Under the section results, the last sentence is not useful. The p value can be added to the previous sentence. We changed the text as you suggested (page 2). We also deleted the last sentence as suggested. Under the section conclusions: I suggest the following: The study showed a statistically significant association between chronic exposure to arsenic and age of menopause. Heavily exposed wome...

Background: Menopause occurs between the ages of 40 and 50, marks end a woman's menstrual cycle. A period time during which woman does not have monthly cycle for more than 12 months is known as post-menopause. Women may suffer challenges in their daily lives this period, such depression, anxiety, sleep loss, all can negative impact on quality life. decrease hormone production, estrogen progeste...

OBJECTIVE This paper seeks to evaluate the ability to deliver term pregnancies following uterine fibroid embolization, and to identify impediments to pregnancy in the embolization procedure. STUDY DESIGN Four physicians performed embolization procedures at various facilities. Patients were asked if fertility was an issue prior to embolization. We measured follicle-stimulating hormone levels b...

In postmenopausal women, the use of aromatase inhibitors increases bone turnover and induces bone loss at sites rich in trabecular bone at an average rate of 1-3% per year leading to an increase in fracture incidence compared to that seen during tamoxifen use. The bone loss is much more marked in young women with treatment-induced ovarian suppression followed by aromatase inhibitor therapy (ave...

The scope of potential fertility issues for pediatric cancer patients is broad and difficult to predict. Both genders are susceptible to central dysregulation of the hypothalamic axis. For boys, chemotherapy and radiation can affect production of both sex hormones and sperm. These effects can be reversible or permanent. For girls, the ovary can be similarly affected, with inadequate or absent h...

Premature ovarian failure (POF) is a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 years (secondary amenorrhea). It is a heterogeneous disorder affecting approximately 1% of women <40 years, 1:10,000 women by age 20 and 1:1,000 women by age 30. The most severe forms present with absent pubertal devel...

BACKGROUND Families with 46,XY Disorders of Sex Development (DSD) have been reported, but they are considered to be exceptionally rare, with the exception of the familial forms of disorders affecting androgen synthesis or action. The families of some patients with anorchia may include individuals with 46,XY gonadal dysgenesis. We therefore analysed a large series of patients with 46,XY DSD or a...