BACKGROUND The initial experience with continuous positive airway pressure (CPAP) may predict subsequent compliance. In a retrospective study, we found that premedication with nonbenzodiazepine sedative-hypnotic agents during CPAP titration polysomnography independently predicted short-term compliance. To validate these findings, we conducted a prospective clinical trial to assess whether preme...

It is now widely accepted that one of the principal functions of premedication is the relief of anxiety in the pre-operative period. This being so, the main problem in quantifying the effects of premedication is the measurement of pre-operative anxiety or the extent to which this has been allayed by premedicant drugs. The measurement of anxiety is a subject which concerns not only the anaesthet...

Atropine has been used in ECT to eliminate parasympathetically mediated dysrhythmias. However, it may increase heart rate and myocardial workload. The aim of this study was to investigate the effect of atropine premedication on the heart rate and blood pressure. Study was performed in 80 patients referred for a course of ECT. They enrolled randomly in one of the two equal groups to receive atro...

PURPOSE Tizanidine is a clonidine derivative and has the same effects, such as sedation, anxiolysis and analgesic response. We evaluated the effect of tizanidine on infiltration pain during epidural catheterization. METHODS Forty patients scheduled to undergo epidural anesthesia in elective surgery were randomly allocated into two groups. The control group received placebo 60 minutes before a...

BACKGROUND Preoperative anxiety is common in pediatric patients. When dexmedetomidine is used alone for sedation as premedication, children tend to awaken when separated from their parents, and body movements occur during invasive procedures. We tested the hypothesis that the combination of dexmedetomidine and ketamine may be a useful premedication to alleviate preoperative anxiety and improve ...

OBJECTIVE To assess clinical efficacy of controlled-release oxycodone (CRO) 20 mg on a 12-h dosing schedule in this prospective, randomised, placebo-controlled, double-blinded study of 40 ASA physical status I-III women undergoing breast surgery for cancer. RESEARCH DESIGN AND METHODS General anaesthesia using remifentanil and propofol was performed for surgery. Both groups received premedica...

BACKGROUND AND PURPOSE Stent-assisted coiling of intracranial aneurysms requires antiplatelet therapy, typically aspirin and clopidogrel to prevent thromboembolic complications. There is a substantial concern that tirofiban may increase the risk of hemorrhage when used as an antiplatelet premedication in ruptured intracranial aneurysms. Our aim was to evaluate the safety and efficacy of intrave...