In this paper design and synthesis of a scaffold comprising primaquine (PQ) motif and cinnamic acid derivatives (CADs) bound directly (compounds 3a-k) or via a spacer (compounds 7a-k) are reported. In the first series of compounds, PQ and various CADs were connected by amide bonds and in the second series by acylsemicarbazide functional groups built from the PQ amino group, CONHNH spacer and th...

A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforw...

The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction seque...

An efficient site selective method for the direct arylation of free-(NH2) adenines 1 to provide a range of C-8 arylated adenines 3 in excellent yields is described. This process based on the use of Pd(OH)2/C as the catalyst and a stoichiometric amount of CuI under ligandless conditions is general. It allows the coupling to proceed with a variety of aryl halides, including for the first time che...

High molecular weight aromatic poly(ether ketone ketone)s were synthesized by the Friedel-Crafts polyacylation condensation of isoand terephthaloyl chlorides with diphenyl ether, 1,4and 1,3-bis(4phenoxybenzoyl)benzenes. Depending on the monomers used for polycondensation, polyketones of regular structure with different iso-/tereisomer repeating unit ratio (100/0, 50/50, 0/100) in the main chain...

Cations of the alkali earth group have strong tendencies to form partially dissociated complexes in solution with the anions of carboxylic acids and other weak acids. The affinity of this association tends to increase with the number of carboxylic acid groups of the acid anion. In a considerable number of cases the effect has been studied quantitatively and expressed in terms of well defined di...

Oximes are highly crystalline materials and oximation is very efficient method for characterization and purification of carbonyl compounds. These compounds not only represent a useful series of derivatives of carbonyl compounds but also may be used as intermediates for the preparation of amides by the Beckmann rearrangement [1], nitrones [2], hydroximinoyl chlorides, nitrile oxide [3] and chi a...