introduction: there are limited reports about selenium status in major thalassemia patients. the aim of this study is evaluation of selenium status in patients with major thalassemia south east of iran with large sample size and wide range of age. this study compared selenium status with other sites of the world. methods: in this study 369 cases that had major thalassemia for more than 5 years ...

The phenotypic and molecular diversity of compound heterozygosity for thalassemic genes in Greece is extensive. The interaction of silent and classic β-thalassemia results in the clinical phenotype of thalassemia intermedia. We report the clinical and hematological findings in an 18-year-old female referred to our hemoglobinopathy prevention unit that was observed to be compound heterozygote fo...

background: hydroxyurea (hu) is a well known chemotherapeutic agent that has been used largely for various myeloproliferative diseases over the past 20 years. in β-thalassemia, the effect of hu is much less clear and remains controversial. this study was undertaken to describe the hematologic and clinical responses of thalassemia major and intermediate patients to hu treatment during 2 years. m...

We prospectively compared a single-tube multiplex polymerase chain reaction (PCR) for detecting alpha-thalassemia with our current approach using 452 blood samples. Initial evaluation of 89 specimens revealed sensitivity and specificity, respectively, for the hemoglobin H inclusion body test (HbH prep) vs PCR for detecting alpha0-thalassemia carriers of 0.79 and 0.96 and for a mean corpuscular ...

background: since the reduction of mental health in patients with thalassemia may affect the quality of life and cause dysfunction in various dimensions, so the assessment of this disorder is necessary to choose the appropriate treatment. therefore, the aim of this study was to investigate the mental health and quality of life in patients with thalassemia major. methods: in this cross-sectional...

β Thalassemia Trait(BTT) produces mild ineffective erythropoiesis and associated increased iron absorption from the gut. Based on these reasons it had been suggested that BTT confers an advantage in maintaining iron balance, in which case prevalence of iron deficiency should be lower in those with the trait. This Study was carried out to determine the frequency of coexistence of iron deficiency...

Introduction: Hemoglobinopathies and thalassemias are the most common single gene disorders in world. World Health Organization figures estimate that 5% of world populations carriers a potentially pathological hemoglobin (Hb) gene. The general incidence thalassemia trait sickle cell anaemia India varies between 3-17% 1-44% respectively3 but because consanguinity, caste area endogamy, some commu...

background: transfusion is the mainstay treatment of patients with thalassemia major and occasionally in thalassemia intermediate. alloimmunization is an unwanted side effect of blood transfusion. the present study intended to determine the frequency of alloimmunization in patients with β- thalassemia major and thalassemia intermediate in southwest iran. patients and methods: this was a cross-s...

The conventional approach to qualitative and quantitative analyses of hemoglobin (Hb) molecules for the diagnoses of hemoglobinopathies requires a combination of tests. We used an automated HPLC (VARIANT) system to study alpha-thalassemia and beta-thalassemia syndromes in Thailand. The beta-thalassemia short program is applicable to the diagnosis of alpha-thalassemia and beta-thalassemia disord...

I enjoyed reading Bilgen et al.’s case report, The effect of HBB: (c*+96T>C (3’UTR+1570 T>C) on the mild β-thalassemia intermedia pheonotype, in the recent issue of the Journal (2011; 28: 219-222). I congratulate the authors for exploring at the molecular level at least one of the thalassemia minima that fits well with the present clinical thalassemia nomenclature. Based on their clinical descr...