Epicutaneous application of the anaesthetic cream Emla (lignocaine and prilocaine), to induce percutaneous anaesthesia in 38 patients scheduled for eyelid skin surgery is presented. The cream was applied 60 to 90 minutes before operation. In 36 out of the 38 patients (94.8%) no supplementary analgesia was required. The pain during the procedure was rated either as no pain in 29 patients (76.3%)...

The vascular effects and duration of action of two ester-linked local anaesthetics, procaine and amethocaine, and four amide-linked local anaesthetics, cinchocaine, lignocaine, mepivacaine and prilocaine, were investigated in 10 volunteers by intradermal injection using a double-blind technique. Procaine and amethocaine produced marked vasodilatation; weal formation was observed at 80% of the a...