There exist many skin-directed and systemic immunomodulating or cytotoxic treatment options for primary cutaneous T- and B-cell lymphomas. However, especially in advanced stages conventional therapies only end in a transient remission without curative results unable to prolong overall survival. Over the last twenty years the high need of new therapeutic strategies resulted in the development of...

BACKGROUND Mutations in BRAF have recently been identified in a significant percentage of primary and metastatic cutaneous malignant melanomas. As ultraviolet (UV) exposure may play a role in the development of cutaneous melanoma lesions with BRAF mutations, BRAF mutation frequency in melanomas arising in sites protected from sun exposure may be lower than those from sun-exposed areas. Thus, we...

BACKGROUND Primary localized cutaneous amyloidosis (PLCA) is a chronic pruritic dermatological disorder of unknown aetiology. Genetic mutations in cases of familial PLCA have been mapped to the oncostatin-M receptor (OSMR) β, a subunit of interleukin (IL)-31 receptor. IL-31 has been implicated in the pathogenesis of atopic dermatitis (AD). OBJECTIVES To assess if AD is more prevalent in patie...

Nodular cutaneous amyloidosis (NCA), the least common form of primary cutaneous amyloidosis, is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue. We present a patient who developed multiple, non-contiguous NCA lesions over a three year period without evidence of systemic disease. We reviewed the literatur...

Primary cutaneous B-cell lymphomas (PCBCLs) are a heterogenous group of rare clonal B-cell lymphoproliferative disorders with distinct clinicopathological features compared with nodal counterparts. It is less frequent than lymphomas of T-cells. Primary cutaneous diffuse large B-cell lymphoma-leg type (PCLBCL-LT) is a rare subtype which constitutes only 4%. It is predominantly seen in elderly pe...

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Mycosis Fungoides (MF) is the most common type of Cutaneous T-Cell Lymphoma (CTCL) and represents nearly 50% of all primary cutaneous lymphomas [1]. MF is characterized by an epidermotropic skin infiltrate of atypical CD4+ phenotype lymphocytes. In a minority of MF cases, the atypical infiltrate is CD8 positive. The later form of CTCL generally follows a rapid, aggressive clinical course [2]. H...

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group of non-Hodgkin lymphomas (NHLs) of T- and B-cell origin where the skin is the primary organ of involvement. This is a case of a 60-year-old Nigerian woman, who was diagnosed and managed as a case of ch...

Primary cutaneous CD8+ small/medium-sized pleomorphic T-cell lymphoma (CD8+ SMPTL) is a rare entity with most probably indolent clinical behaviour. Several cases with facial localisation, mostly localised to the ear, have previously been described (1). Reports of extrafacial involvement are limited, and mostly involve acral sites such as the hands and feet. The classification concerning this ra...

Cutaneous Lymphomas (CL) are a distinctive group of lymphomas; they are the second most frequent extra nodal lymphomas. They can be defined as lymphoproliferative skin infiltrates of T-, Bor NKcell lineage which typically occur in and remain confined to the skin without detectable extracutaneous manifestation 1. The Cutaneous T-cell Lymphoma (CTCL) spectrum is composed of Mycosis Fungoides (MF)...