We report the case of a 64-year-old man who presented with severe hypercalcaemia secondary to primary hyperparathyroidism. Soon after admission he developed ventricular fibrillation with no other cause than this severe hypercalcaemia. Although the occurrence of cardiac arrhythmias in hypercalcaemia is widely known, ventricular fibrillation has never been described before.

INTRODUCTION Primary hyperparathyroidism is a common endocrine disorder with different epidemiological patterns among countries. In Denmark, the incidence of primary hyperparathyroidism was last described in 1999 when it was reported to follow an increasing trend. In the present study, we evaluated trends in the incidence of primary hyperparathyroidism in Denmark up to 2010. MATERIAL AND METH...

The bone mineral density increments in patients with sporadic primary hyperparathyroidism after parathyroidectomy have been studied by several investigators, but few have investigated this topic in primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Further, as far as we know, only two studies have consistently evaluated bone mineral density values after parathyroid...

homeostatsis and the pathophysiology of disorders associated with abnormal CaSR activity including familial hypocalciruic hypercalcemia, neonatal severe hyperparathyroidism, and secondary hyperparathyroidism. The CaSR, a member of superfamily of G-protein-coupled receptors, has a large extracelluar domain and seven membrane-spanning segments (1). This receptor is localized on the surface of var...

BACKGROUND In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anaesthetic management differs function of etiology (primary vs. secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy). OBJECTIVES To evaluate peri-operative management (focusing on hemodynamic changes, cardiac arrhythmias and patients'...

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Eight patients suffering from primary hyperparathyroidism and diabetes mellitus are reported. All of the patients are female. The clinical problems resulting from the co-existence of these two endocrine disorders and the similarity of their symptoms are discussed. The experience from a large diabetic clinic population suggests that the association of hyperparathyroidism with diabetes merits fur...

BACKGROUND Prophylactic administration of calcitriol has been suggested to mitigate the risk of hypocalcemia after parathyroidectomy. The effect of calcitriol on postoperative serum ionized calcium concentrations has not been evaluated in dogs after parathyroidectomy. HYPOTHESIS/OBJECTIVES To determine the effect of prophylactic calcitriol administration on postoperative serum ionized calcium...

We report a Japanese pedigree with familial primary hyperparathyroidism due to a CDC73 mutation. To our knowledge, this is the first report of cinacalcet as a treatment for CDC73-related primary hyperparathyroidism. The proband had severe psychomotor retardation and received laryngotracheal separation surgery. At 19 yr of age, he developed acute pancreatitis. Hypercalcemia (12.2-13.8 mg/dL), el...

Brown tumor represents a serious and late bony complications of advanced hyperparathyroidism with a frequency of 1.5–1.75 percent in secondary hyperparathyroidism and 3–4 percent in primary hyperparathyroidism. [1,2] Here we describe an extremely rare case of a 19-year-old male patient with a brown tumor localised in the maxilla and mandibular due to secondary hyperparathyroidism compromising m...