نتایج جستجو برای: primordial follicle
تعداد نتایج: 32923 فیلتر نتایج به سال:
INTRODUCTION During mammalian ovarian organogenesis, the massive loss of oogonia via apoptosis is attenuated by the association of germ cells with somatic mesoepithelial cells of the gonadal ridge to form primordial follicles. It is suspected that the germ cell actively participates in this process via the production of local regulatory factors. Growth differentiation factor-9 (GDF-9), a member...
Females are born with a finite number of primordial follicles. 4-Vinylcyclohexene diepoxide (VCD) is a metabolite formed by epoxidation of 4-vinylcyclohexene (VCH) via its two monoepoxides 1,2- and 7,8-4-vinylcyclohexene monoepoxide (VCM). VCD specifically destroys small preantral (primordial and small primary) follicles in the rodent ovary. The phase I enzyme, cytochrome P450 isoform 2E1 (CYP2...
We investigated the effects of different windows of testosterone propionate (TP) treatment during foetal and neonatal life in female rats to determine whether and when excess androgen exposure would cause disruption of adult reproductive function. Animals were killed prepubertally at d25 and as adults at d90. Plasma samples were taken for hormone analysis and ovaries serial sectioned for morpho...
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