Thirty-five patients with typical Prinzmetal's variant angina were studied by coronary cineangiography. There was no demonstrable stenosis of the major coronary arteries in 19 patients. Nine patients with single coronary stenosis underwent aortocoronary bypass and had recurrence of the symptoms postoperatively. Administration of nifedipine effected complete cessation of the symptoms among patie...

ergic blocking effects of iproveratril. Can J Physiol Pharmacol 43: 339, 1965 22. Greenberg S, Wilson WR: Iproveratril: a nonspecific antagonist of peripheral vascular reactivity. Can J Physiol Pharmacol 52: 266, 1974 23. Ross G, Jorgensen CR: Cardiovascular actions of iproveratril. J Pharmacol Exp Ther 158: 504, 1967 24. Rowe GG, Stenlund RR, Thomsen JH, Corliss RJ, Sialer S: The systemic and ...

A lack in prostacyclin (PGI2) production due to atherosclerosis may play a role in the pathophysiology of some of the clinical manifestations of ischemic heart disease and in particular, of coronary vasospasm. We therefore evaluated the effects of i.v. PGI2 in nine patients with variant angina and six normal volunteers. In normal subjects, PGI2 (2.5, 5, 10 and 20 micrograms/kg/min) had signific...

A 65 year old woman with gall stones presented with crushing chest pain after an attack of biliary colic. The electrocardiogram showed ST segment elevation in leads I, aVL, and V1-V3 while leads II, III, and aVF showed ST segment depression. Cardiac enzyme activity remained within the normal range. During the next three weeks attacks of epigastric and right hypochondrial pain preceded by crushi...

A case of Prinzmetal variant angina with transient complete atrioventricular block and syncopal episodes following an anteroseptal myocardial infarction is described. The syncopal attacks were not prevented by demand cardiac pacing and were presumably caused by transient severe ischaemia of the left ventricle, with a consequent reduction in cardiac output. The left ventriculogram showed a large...

CUnical data, coronary &nographic findings and results of surgery are analyzed in six patients with Pfhzmetars variant angina who underwent saphenous vein aorta to coronary bypass. Eighteen additional cases from the literature are also surveyed. Postoperatively, only 38 percent (9 of 24) of the entire surgically m e d group were free of pain with no evidence of myocardial infarction. There was ...

and clinical illustrations. Am J Cardiol 90: 624, 1978 12. Guazzi M, Polese A, Fiorentini C, Magni F, Bartorelli C: Left ventricular performance and related haemodynamic changes in Prinzmetal's variant angina pectoris. Br Heart J 33: 84, 1971 13. Maseri A, Mimmo R, Chierchia S, Marchesi C, Pesola A, L'Abbate A: Coronary artery spasm as a cause of acute myocardial ischemia in man. Chest 68: 625,...

A 24-year-old male student had three myocardial infarctions, one prior to and two following the angiographic documentation of normal coronary arteries. A spontaneous episode of variant angina prompted repeat coronary angiography, during which intravenous ergonovine caused spasm of the left anterior descending coronary artery, transient ST-segment elevation, and ischemic chest pain; the previous...

Ergonovine provocation test is known to be very sensitive for diagnosing variant angina. The patient described in this study initially presented with atypical chest pain and underwent coronary angiography and ergonovine provocation tests, which were negative. The patient was subsequently prescribed a proton pump inhibitor and prokinetics for pain relief, but then presented with acute myocardial...