The patient was a 32-year-old woman diagnosed 18 months earlier with nodular sclerosing Hodgkin lymphoma, Ann Arbor stage IIIA (supradiaphragmatic and infradiaphragmatic lymph node involvement and absence of B symptoms). She had initially been treated with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine). On recurrence of the lymphoma, she was treated with 2 cycles of c-MO...

The curability of the aggressive, large-cell lymphomas was first convincingly reported by Levitt et al in 1972.[1] Patients with “reticulum cell sarcoma” were treated with a regimen that came to be known as COMLA (cyclophosphamide, vincristine [Oncovin], methotrexate, leucovorin, cytarabine [Ara-C]). A more commonly quoted paper was published in 1975 by DeVita et al describing the cure of advan...

Constitutional pure red cell aplasia (CPRCA) is a syndrome of failed erythropoiesis usually diagnosed within the first year of life. Four patients with CPRCA received transplants with marrow from their HLA-identical, mixed lymphocyte culture-nonreactive siblings. All patients were resistant to corticosteroid therapy and were dependent on regular red cell transfusions for at least 5 years. Three...

Approximately 8,200 new cases of Hodgkin lymphoma are diagnosed annually in the United States. Common presenting features include painless lymphadenopathy (usually above the diaphragm), cough, fever, night sweats, and weight loss. To decrease late complications, treatment has gradually evolved toward shorter-duration chemotherapy with use of lower-dose, shorter-duration radiation therapy. ABVD ...

Tumours of the central nervous system are intrinsically more dangerous than tumours at other sites, and in particular, brain tumours are responsible for 3% of cancer deaths in the UK. Despite this, research into new therapies only receives 1% of national cancer research spend. The most common chemotherapies are temozolomide, procarbazine, carmustine, lomustine and vincristine, but because of th...

The curability of the aggressive, large-cell lymphomas was first convincingly reported by Levitt et al in 1972.[1] Patients with “reticulum cell sarcoma” were treated with a regimen that came to be known as COMLA (cyclophosphamide, vincristine [Oncovin], methotrexate, leucovorin, cytarabine [Ara-C]). A more commonly quoted paper was published in 1975 by DeVita et al describing the cure of advan...