A recent study in Science finds that α/β-hydrolase domain-containing protein 2 (ABHD2) is a novel nongenomic progesterone receptor that holds the CatSper cation channel open while progesterone elevates sperm cytoplasmic calcium ion (Ca) levels and triggers sperm hyperactive motility. ABHD2 functions as a lipid hydrolase, breaking down arachidonoylglycerols (2-AG/1AG)—endocannabinoid components ...

HULL, E. Effects o f neonatal exposure to progesterone on sexual behavior o f male and female rats. PHYSIOL. BEHAV. 26(3) 401--405, 1981 .--Lactating females received daffy injections of progesterone or off, and their offspring were gonadectomized in adulthood and tested for both musculine and feminine sexual behavior elicited by estrogen, progesterone, and testosterone regimens. Male offspring...

Over 100 million women use progesterone therapies worldwide. Despite having immunomodulatory and repair properties, their effects on the outcome of viral diseases outside of the reproductive tract have not been evaluated. Administration of exogenous progesterone (at concentrations that mimic the luteal phase) to progesterone-depleted adult female mice conferred protection from both lethal and s...

Progesterone, an agonist for the progesterone receptor (PR), can be an efficacious and well-tolerated treatment in endometrial cancer. The clinical use of progesterone is limited because of the lack of biomarkers that predict hormone sensitivity. Despite its efficacy in cancer therapy, mechanisms and site of action for progesterone remain unknown. Using an in vivo endometrial cancer mouse model...

since the uterine is a sensitive tissue to steroid hormones, the aim of the present study was to investigate the effects of 17β-estradiol (e2) and progesterone (p4) alone or in combination on morphological and morphometrically parameters of ovariectomized mouse uterus.adult virgin female mice (8-10 weeks old)were ovariectomized and treated with e2, p4, e2 followed by p4 and the oil vehicle alon...

background: the preparation of endometrium for embryo reception is dependent on the ovarian hormones, which are affected by ovarian hyperstimulation procedure. objective: the aim of this study was to evaluate the changes in morphometrical indices of endometrium by the daily injection of progesterone after mouse ovarian induction. materials and methods: adult virgin female mice were selected and...

background: while traditional semen parameters are of significant clinical value, total fertilization failure in ivf cycles is not uncommon. sperm function testing such as; hamster egg penetration test has severed limitations as a clinical test. the aim of this study was to evaluate the predictive value of semen parameters by using of intracellular calcium [ca2+]i increase in response to proges...

objective(s): the aim of this study is to determine the effects of progesterone treatment on the survival of random skin flaps. materials and methods: mcfarlane flaps were established and 40 male rats were randomly assigned to the progesterone-treated as the test group or normal saline-treated as the control group. progesterone or normal saline (10 mg/kg) was administered intraperitoneally once...

Effects of testosterone. progesterone. oestrogen and progesterone combination were studied on thiopentone sodium-induced general anaesthesia in nonpregnant female and male rabbits. Three days' treatment either with testosterone 1 mg/kg or progesterone 1 .5 mg/kg or oestrogen 0.03 mg in combination with progesterone 0.5 mg/kg delayed the onset and shortened the duration of oeneral anaesthesia.