................................................................................................................... vi LIST OF TABLES ......................................................................................................... xiv LIST OF FIGURES ........................................................................................................ xv CHAPTER 1. PROGESTIN MECHANIS...

Prostaglandin F~(Y, (PGF2a) causes luteolysis in several species of animals including cattle and sheep. This has led to investigations with PGF2a as an agent for the control of oestrus and ovulation in domestic animals (Inskeep 1973) and to comparison of PGF2a and progestins as practical methods of synchronizing oestrus in cattle (Smith 1973). This paper reports preliminary studies of the use o...

Menopausal hormone decline contributes significantly to the risk of osteoporosis. Therapies for treating osteoporosis, such as hormone replacement therapy (estrogen or combination estrogen-progestins), inhibit bone resorption. Both animal and human studies demonstrate phytoestrogenic soy isoflavones favorably impact bone health. The exact mechanism is still unclear. Additional research is neede...

Norethindrone was the first progestin, a synthetic version of a natural steroid hormone, progesterone. A few birth control pills contain only a progestin, while the rest combine a progestin and an estrogen analogue. In the more than 60 years since Djerassi’s landmark synthesis, drug makers have experimented with different formulations of oral contraceptives, including introducing new types of p...