The present study aimed to evaluate the GSH and MDA levels in dog’s serum vital organs of aborted fetuses, after application two abortifacient. Animals group I (n = 6) were treated twice with subcutaneous injection 10 mg/kg aglepristone II 3) received prostaglandin F2α at a dose 125 μg/kg every 12 hours until abortion process completed. Hematologic examinations sedimentation rates performed bit...

Background: One of the most common and dangerous consequences in individuals with decompensated cirrhosis is SBP. Early antibiotic treatment crucial for effective lowering death rate. A modulator immune response infection PGE2. Aim Study: To analyze how Prostaglandin E2 ascites polymorphic nuclear cell count affect cirrhotic diseased individual mortality prognosis.

Prostaglandin analogues of the E-series theoretically offer the ideal antiulcer drugs. Peptic ulcer healing with prostaglandin analogues is, however, no better than would be predicted from their ability to inhibit gastric acid secretion and they are less effective than histamine H2 receptor antagonists in preventing ulcer relapse. It could be that prostaglandin analogues inhibit gastric mucosal...

Platelets provide an accessible and homogeneous cellular system for investigative studies on hypertension. Hypertension-associated abnormalities of cyclic adenosine 3,5-monophosphate (AMP) metabolism were studied in human platelets. Platelets from hypertensive subjects had an enhanced cyclic AMP accumulation response to prostaglandin E, (twofold increase in prostaglandin Ei sensitivity). The de...

In a previous study we observed that the ability of intravenous infusions of prostaglandin I2 to attenuate vasoconstriction caused by intravenous infusions of angiotensin II was reduced in the renal but not mesenteric vasculature of spontaneously hypertensive rats (SHR). One objective of the current study was to determine whether a renal defect in the angiotensin II/prostaglandin I2 interaction...

The effect of prostaglandin I2 and two other vasodilator agents, acetylcholine and sodium nitroprusside, on systemic and renal circulation was studied in 29 adult euvolemic Sprague-Dawley rats. Intra-aortic infusion of prostaglandin I2 (3.6 micrograms/kg/hr; n = 6 rats) produced significant vasodilation (p less than 0.05), as indicated by an average reduction in total peripheral vascular resist...

OBJECTIVE A novel prostaglandin F2alpha receptor antagonist, THG113.31, was tested for the suppression of uterine contractility and delay of preterm labor in sheep. STUDY DESIGN We determined the tocolytic effectiveness of THG113.31 on contractions that were stimulated in vitro by prostaglandin F2alpha and E2 in longitudinal and circular myometrial strips. We also tested the ability of THG113...