INTRODUCTION Prostatic blue nevus was first described as a benign lesion of uncertain and controversial histogenesis by Nogogosyan in 1963. Currently, 30 cases have been reported in the world literature. CASE PRESENTATION A 63-year-old Hispanic man presented with prostatism of several months' evolution. Histopathological examination revealed a blue nevus associated with nodular hyperplasia an...

The multifocal origin of prostate cancer suggests a pan-organ defect in a tumor suppressor pathway. Although structural mutations in the p53 gene have been implicated in late-stage prostate cancer, little is known about the p53 response to genotoxic stress in normal human prostatic epithelial cells from which adenocarcinomas originate. We found that the majority (10 of 12) of epithelial cell cu...

References 1. Steers WD. 5 -Reductase activity in the prostate. Urology 2001;58:17–24. 2. Horton R, Hsieh P, Barberia J, Pages L, Cosgrove M. Atered blood androgens in elderly men with prostate hyperplasia. J Clin Endocrinol Metab 1975;41: 793–6. 3. Wright F, Poizat R, Bongini M, Doukani A, Mauvais-Jarris P. Decreased urinary 5 -androstane-3 ,17 -diol glucuronide excretion in patients with beni...

Benign prostatic hyperplasia (BPH) is a common disease in human that gradual overgrowth of the prostate gland leads to impinge on the urethra with impairment in urinary function. Numerous plants improve uncontrolled growth of the prostate gland and improve urinary tract symptoms associated with BPH. In this study, 25 healthy adult male Wistar rats were divided randomly in five groups: G1 (Contr...