The mechanistic/mammalian target of rapamycin (mTOR) is considered to be an atypical protein kinase that plays a critical role in integrating different cellular and environmental inputs the form growth factors, nutrients energy and, subsequently, regulating events, including cell metabolism, survival, homeostasis, differentiation. Immunologically, mTOR regulator immune function through numerous...

Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms compound celastrol derived from medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related retrieved GeneCards, DisGeNET, T...