protein stability

Knowing the mechanisms by which protein stability change is one of the most important and valuable tasks in molecular biology. The conventional methods of predicting protein stability changes mainly focus on improving prediction accuracy. However, it is desirable to extract domain knowledge from large databases that is beneficial to accurate prediction of the protein stability change. This pape...

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inhibitory effect of corcin on aggregation of 1n/4r human tau protein in vitro

Journal: :iranian journal of basic medical sciences 0

ali mohammadi karakani institute of biochemistry and biophysics, university of tehran, tehran, iran gholamhossein riazi institute of biochemistry and biophysics, university of tehran, tehran, iran seyed mahmood ghaffari institute of biochemistry and biophysics, university of tehran, tehran, iran shahin ahmadian institute of biochemistry and biophysics, university of tehran, tehran, iran farzad mokhtari institute of biochemistry and biophysics, university of tehran, tehran, iran mahshad jalili firuzi institute of biochemistry and biophysics, university of tehran, tehran, iran

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

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