We lost a star scientist this summer, Tony Pawson, who made incredible contributions in his shortened career to our understanding of the biochemical mechanisms of cell signaling. Tony, a Canadian of British origin, performed groundbreaking research spanning nearly 40 years that provided tremendous insight into how biochemical signals communicate information both between and inside cells. He was...

drug interaction may cause sever adverse drug reactions in patients. the high amounts of prescribed medication in hospitalized patients will cause higher incidence of drug interactions. therefore, the study of drug interactions in hospitalized patients seems to be worth. we have, studied drug interaction in internal and surgical units, in kashani hospital in shahrekord. factors included in this...

literature and culture are two inseparable issues. when we talk about the culture, the literature can also appear unconsciously, because the culture is composed of thoughts, feelings and emotions and the styles and personal ways of society, which as a general rule, can appear in terms of principles and respectful rules. the literature on the other hand, discloses and transmits these concepts to...

with the rapid emergence of 3d applications and virtual environments in computer systems; the need for a new type of interaction device arises. this is because the traditional devices such as mouse, keyboard, and joystick become inefficient and cumbersome within these virtual environments. in other words, evolution of user interfaces shapes the change in the human-computer interaction (hci). in...

In determining protein-protein interactions in native muscle membranes biochemically, bifunctional crosslinking agents of various length and solubility have been established as effective tools. Gel electrophoretic and immunoblotting methodology have proven to be highly suitable for the analysis of crosslinked products. Here, we have analysed the oligomeric status of a well established muscle me...

Popular online enrichment analysis tools from the field of molecular systems biology provide users with the ability to submit their experimental results as gene sets for individual analysis. Such queries are kept private, and have never before been considered as a resource for integrative analysis. By harnessing gene set query submissions from thousands of users, we aim to discover biological k...

Mining frequent subgraphs is an important operation on graphs; it is defined as finding all subgraphs that appear frequently in a database according to a given frequency threshold. Most existing work assumes a database of many small graphs, but modern applications, such as social networks, citation graphs, or proteinprotein interactions in bioinformatics, are modeled as a single large graph. In...

Consistency and Sensitivity Analysis of Multi-level Petri Net Models of Biological Systems Shauheen Zahirazami Doctor of Philosophy Concordia University 2013 The recent developments in biological experiments have awarded the research community with valuable information, which describe finely regulated systems that govern the cell dynamics. One of the greatest challenges, however, remains to rep...

The study of proteomics reached unexpected levels of interest, as a direct consequence of its discovered influence over some complex biological phenomena, such as problematic diseases like cancer. This paper presents a new technique that allows for an accurate analysis of the human interactome network. It is basically a two-step analysis process that involves, at first, the detection of each pr...