Submit Manuscript | http://medcraveonline.com Abbreviations: EC50: Half Maximal Effective Concentration; MIC: Minimum Inhibitory Concentration; TLC: Thin-Layer Chromatography; PTLC: Preparative Thin Layer Chromatography; FTIR: Fourier Transform Infrared Spectroscopy; HRMS E: High-Resolution Mass Spectrometer Electron Ionization; 1H NMR; Proton Nuclear Magnetic Resonance; 13C NMR; Carbon Nuclear...

The diagnosis of intracranial focal lesions based on imaging studies is a challenge. In brain abscess, proton magnetic resonance spectroscopy (1H-MRS) is useful to define etiology, differentiating anaerobic from aerobic pathogens and inclusive sterile abscess based on the behavior of certain metabolites. We report a patient with Rendu-Osler-Weber syndrome, pulmonary arteriovenous fistulas, and ...

Formation of amyloid oligomers, the most toxic species of amyloids in degenerative diseases, is critically coupled to the interplay with surrounding water. The hydrophobic force driving the oligomerization causes water removal from interfaces, changing the surface-hydration properties. Here, we show that such effects alter the magnetic relaxation response of local water in ways that may enable ...

In the absence of water signal suppression, the proton magnetic resonance spectroscopy ((1)H MRS) in vivo water resonance signal-to-noise ratio (SNR) is orders of magnitude larger than the SNR of all the other resonances. In this case, because the high-SNR water resonance dominates the data, it is difficult to obtain reliable parameter estimates for the low SNR resonances. Herein, a new model i...

Creativity is a vast construct, seemingly intractable to scientific inquiry-perhaps due to the vague concepts applied to the field of research. One attempt to limit the purview of creative cognition formulates the construct in terms of evolutionary constraints, namely that of blind variation and selective retention (BVSR). Behaviorally, one can limit the "blind variation" component to idea gene...