background: health workers ability to provide high quality care can be adversely affected by many factors such as sleep deprivation associated with shift work. the aim of this study was to compare sleep disorders among shift workers and non-shift workers in kermanshah hospital (2005) methods: at first, demographic information of the participants were gathered. 653 volunteers were divided into t...

‎In this paper‎, ‎we generalize the proximal point algorithm to complete CAT(0) spaces and show‎ ‎that the sequence generated by the proximal point algorithm‎ $w$-converges to a zero of the maximal‎ ‎monotone operator‎. ‎Also‎, ‎we prove that if $f‎: ‎Xrightarrow‎ ‎]-infty‎, +‎infty]$ is a proper‎, ‎convex and lower semicontinuous‎ ‎function on the complete CAT(0) space $X$‎, ‎then the proximal...

The processes which are involved in the development of the normal outflow tracts of the ventricles are the following: The ostium bulbar torsion accounts for the concordant flow between the ventricles and the proximal conuses. The leftward shift of the ostium bulbi accounts for the partial overriding of the aorta over the left ventricle. The truncal rotation accounts for the twisted relationship...

Known transcription factor-DNA interactions in the minimal enhancer of the murine interleukin-2 gene (IL-2) do not easily explain the T cell specificity of IL-2 regulation. To seek additional determinants of cell type specificity, in vivo methodologies were employed to examine chromatin structure 5' and 3' of the 300 bp IL-2 proximal promoter/enhancer region. Restriction enzyme accessibility re...

Cytokine secretion profiles of activated T cells are critical for maintaining the immunologic balance between protection and tolerance. In mice, several cytokines have been reported to exhibit monoallelic expression. Previously, we found that the human interleukin-1 alpha (IL1A) gene exhibits a stable allele-specific expression pattern in CD4+ T-cell clones. We investigated whether DNA methylat...

Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct. How these regions arise during development is poorly understood. The zebrafish pronephros consists of two linear nephrons that develop from the intermediate mesoderm along the length of the trunk. Here we show that, contrary to current d...

The frizzled signaling/signal transduction pathway controls planar cell polarity (PCP) in both vertebrates and invertebrates. Epistasis experiments argue that in the Drosophila epidermis multiple wing hairs (mwh) acts as a downstream component of the pathway. The PCP proteins accumulate asymmetrically in pupal wing cells where they are thought to form distinct protein complexes. One is located ...

We have characterized the proximal promoter region of the human COL11A1 gene. Transient transfection assays indicate that the segment from -199 to +1 is necessary for the activation of basal transcription. Electrophoretic mobility shift assays (EMSAs) demonstrated that the ATTGG sequence, within the -147 to -121 fragment, is critical to bind nuclear proteins in the proximal COL11A1 promoter. We...

Troponin I is a thin-filament contractile protein expressed in striated muscle. There are three known troponin I genes which are expressed in a muscle-fibre-type-specific manner in mature animals. Although the slow skeletal troponin I isoform is expressed in fetal and neonatal heart, the cardiac isoform is restricted in its expression to the myocardium at all developmental stages. To study the ...

background: today, obesity is considered as a health problem that increases the risk of some diseases. therefore, identifying the effective factors on obesity is of great importance. shift work is one of the indicators for increased risk of obesity in society and also shift work may cause various health problems for workers in military organizations. the current study aimed to investigate the r...