Intrusive mental experiences occur within posttraumatic stress disorder (PTSD) and some psychotic disorders. Similarities in the phenomenology and content in the intrusions of both disorders have been noted. Currently there is little understanding of any common etiology in terms of information-processing styles. This study investigated predictors of analogue posttraumatic intrusive cognitions w...

Complete genital self-mutilation (GSM), mostly a non-suicidal behavior, is a rare occurrence among patients with psychotic and non-psychotic disorders. This case report is on a patient who, in the shadow of severe psychotic manifestations with overwhelming socio-cultural contents, completely self-mutilated his external genitals. Emergency surgical and psychiatric management improved his conditi...

BACKGROUND Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap with regard to symptoms, structural and functional brain abnormalities, and genetic risk factors. Neurobiological pathways connecting genes to clinical phenotypes across the spectrum from schizophrenia to psychotic bipolar disorder remain largely unknown. METHODS We examined the relationship between str...

BACKGROUND Personality is considered as an important aspect that can affect symptoms and social function in persons with schizophrenia. The personality questionnaire Swedish universities Scales of Personality (SSP) has not previously been used in psychotic disorder. AIMS To investigate if SSP has a similar internal consistency and factor structure in a psychosis population as among healthy co...

IMPORTANCE Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disor...

IMPORTANCE Structural alterations in the hippocampus and other medial temporal lobe regions have been observed in schizophrenia. How these alterations and hippocampal subfields might differ across the psychosis spectrum remains unclear. OBJECTIVES To characterize medial temporal lobe structures, including hippocampal subfields, using magnetic resonance imaging and to examine their relation to...

BACKGROUND Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure and eye movement desensitization and reprocessing (EMDR) for PTSD in patients w...

Substances such as alcohol, cocaine, amphetamine, and cannabis can produce psychotic reactions in individuals who are otherwise free of serious mental illness. However, persons with primary psychotic disorders, such as schizophrenia and bipolar disorder, who use these substances often present for treatment with signs and symptoms similar to those whose psychosis resulted from the use of drugs a...

INTRODUCTION Psychotic symptoms are highly prevalent in adolescents with 22q11.2 Deletion Syndrome (22qDS), with as many as half reporting transient psychotic symptoms. Anxiety is also commonly seen in this population, and patients frequently report both psychotic symptoms and anxiety. OBJECTIVE To describe the psychiatric presentation, course and management of primary anxiety disorders in pa...

BACKGROUND Conflicting evidence exists about the relationship between psychotic symptoms and suicidality in mood disorders. We aimed to investigate the lifetime suicidality and its relationship with dimensions of the psychotic spectrum over the lifespan among subjects with bipolar I (BD I) or major depressive disorder (MDD). METHODS 147 Consecutive out- and inpatients with BD I or MDD present...