Abstract In this paper we present design and analysis of RF MEMS switches with crab-leg connection beam structures. The mechanical characteristics of switch including pull down voltage, hysteresis analysis and capacitance between beam and center conductor are studied. RF characterization of the switch including insertion loss, return loss and isolation are also investigated. Measurement results...

BACKGROUND The neuronal guidance molecule Slit2 plays suppressive role in tumorigenesis and progression. We previously showed that Slit2-Robo1 inhibit cell migration in colorectal cancer (CRC). However, little is known about its downstream effectors in CRC. This study tries to identify whether the Slit-Robo Rho GTPase activating protein 1 (srGAP1) could mediate the inhibitory effect of Slit2-Ro...

BACKGROUND This study was designed to obtain the chemical fingerprint and to investigate the effect of Phyllanthus urinaria on telomerase activity and apoptotic pathways in the human nasopharyngeal carcinoma cell line (NPC-BM1). MATERIALS AND METHODS The polyphenol compounds in P. urinaria were investigated by HPLC/MS. Cell viability with the treatment of P. urinaria, gallic acid, ellagic aci...

Background: Nasopharyngeal carcinoma (NPC) remains as a devastating malignancy due to a lack of effective therapy for recurrence and metastasis. Salvianolic acid A (SAA), a compound extracted from Salvia miltiorrhiza, possesses a variety of biological properties such as antioxidant, antithrombotic, myocardial ischemia protection and anti-hepatic-fibrosis. However, the effect of SAA on NPC cells...

Purpose: To explore the anti-hepatoma effect of Gan-Ai-Xiao Decoction (GAXD), a folk remedy. Methods: High performance liquid chromatography (HPLC) was used to identify the major chemical components of GAXD ethanol extract (EE). The cytotoxic effect of GAXD EE against HepG2 cells was measured by methyl thiazolyl tetrazolium (MTT) assay. Flow cytometry and Western blot were used to study the eff...

Abstract A large number of researches have shown that circular RNA (circRNA) is new hope for the diagnosis or treatment tumors, including liver cancer (LCa). However, it remains largely unclear role circRNA in progression LCa and its molecular mechanism. GSE164803 microarray dataset was applied to identify dysregulated circRNAs noncancerous tissues. CircTUBGCP5 (hsa_circ_0034049) selected furth...

ALG-2 (apoptosis-linked gene 2) is a Ca2+-binding protein that belongs to the PEF (penta-EF-hand) protein family. Alix (ALG-2-interacting protein X)/AIP1 (ALG-2-interacting protein 1), one of its binding partners, interacts with TSG101 and CHMP4 (charged multivesicular body protein 4), which are components of ESCRT-I (endosomal sorting complex required for transport I) and ESCRT-III respectivel...