OBJECTIVES This study investigated the pharmacologic effect of endothelin receptor antagonists on cardiopulmonary hemodynamic variables in a beagle model of pulmonary hypertension. BACKGROUND We recently developed a beagle model of pulmonary hypertension that allows accurate determination of cardiopulmonary hemodynamic variables and is associated with elevated plasma endothelin-1 concentratio...

Widespread availability of Doppler echocardiography, combined with increasing community awareness of pulmonary arterial hypertension (PAH) as an important and treatable disease, results in frequent referral of patients with suspected PAH to tertiary pulmonary hypertension centres. While this state of affairs is laudable, it does result in substantial numbers of patients who turn out not to have...