PDE3s belong to the phosphodiesterases family, where the PDE3A isoform is the major subtype in platelets involved in the cAMP regulation pathway of platelet aggregation. PDE3A inhibitors have been designed as potential antiplatelet agents. In this work, a homology model of PDE3A was developed and used to obtain the binding modes of bicyclic heteroaromatic pyridazinones and pyrazolones. Most of ...

Alzheimer hastalığı (AH), demansın en yaygın nedeni olan kronik nörodejeneratif bir hastalıktır. Hastalığa yakalanma riski yaşla birlikte artar. Hastalığın histopatolojisi incelendiğinde senil amiloid plakları, nörofibriler yumak oluşumu, sinaps-nöron kaybı ve beyinde belirgin atrofi saptanır. hastalığında asetilkolin sentezinden sorumlu kolin asetil transferaz düzeyindeki azalma %58-90'dır. Me...

The photosynthetic activities of barley leaves in vivo and o f thylakoids, isolated from the leaves, in vitro were studied during greening in the presence or absence of 2 x 10-4 m SAN 6706. The degree o f chlorophyll bleaching increased from 32% at 24 h o f greening to 60% at the final stage. Treated leaves were unable to carry out 14C 0 2-fixation, their fluorescence induction properties showe...

Among chlorosis-inducing herbicides that interfere with carotenoid synthesis two groups o f different potency can be discriminated (group 1; aminotriazole amd haloxidine; group 2 with more extensive photodestructions: pyridazinone herbicides and difunon). After application of herbicides o f group 2 colored carotenoids were completely absent and preexisting chlorophyll was degraded by photochemi...

Photosynthesis, Electron Transport, Chlorophyll Fluorescence, Photosystem II, BAS 13-338 Addition of BAS 13-338 (4-chloro-5-dim ethylam ino-2-phenyl-3(2H )-pyridazinone) to a sus­ pension of chloroplast thylakoids caused an increase in the / level o f chlorophyll fluorescence induction without affecting the F0 level and with a slight decrease in the Fmax level in a manner similar to the additio...

Levosimendan is a pyridazinone-dinitrile derivative belonging to a new class of cardiac inotropic drugs, Ca++ sensitizers. Levosimendan is also a vasodilator both in vitro and in vivo, but its mechanism is not well understood. The cardiac target protein of levosimendan, troponin C, is a Ca++-binding EF-hand protein. This raises the possibility that levosimendan may also interact with smooth mus...