1. Evidence is presented for the presence of pyridoxine phosphate oxidase in aqueous extracts of Escherichia coli. Some comparison is made with pyridoxamine phosphate oxidase. 2. Isoniazid and iproniazid were found to combine with pyridoxal phosphate, but isoniazid did not combine with either pyridoxamine phosphate or pyridoxine phosphate. Both oxidase activities were somewhat inhibited by benz...

Complications of long-term linezolid administration include anemia and thrombocytopenia. A recent report has suggested that pyridoxine may prevent myelosuppression. Pyridoxine was administered to 24 patients with bone infections who were being treated with linezolid. Thrombocytopenia occurred in 11 patients (45.8%), and anemia occurred in 6 (25%). We concluded that treatment wtih pyridoxine is ...

Rifampicin-resistant tuberculosis (RR-TB) is a global public health problem caused by mycobacterium resistant to Rifampicin. Drug-induced peripheral neuropathy and neurotoxicity are well-known adverse effects of treatment regimens that cause significant morbidity. Pyridoxine often added for the prevention and/or these side effects. The basis effectiveness this practice unclear. We conducted sys...

The concentrations of serotonin in various brain areas were significantly decreased in the pyridoxine-deficient young rat. There was no change in the concentration of dopamine. Both Bmax and Kd of [3H]serotonin binding to membrane preparations from cerebral cortex were increased in deficiency and were restored to normal upon pyridoxine supplementation. There was no change in [3H]spiroperidol bi...

The incidence of granulocytopenia in a series of 5,745 cases of thiouracil administration has been reported to be 2.5%o,8 and clinical studies have suggested that pyridoxine in large doses is of value in restoring the blood picture to normal.' The present experiments were devised to determine (a) if granulocytopenia could be induced in pyridoxine-deficient and in adequately fed mice by the use ...

OBJECTIVES To determine pineal response to pyridoxine in normal men. MATERIAL AND METHODS Twelve healthy men were given orally pyridoxine (100 mg) or placebo at 1700h. Serum melatonin levels were determined every 30 minutes with simultaneous measurement of core body temperature between 1700h to 0300h. Polysomnographic sleep recordings were performed between 1800h to 2000h. RESULTS Serum mel...

1. Evidence of deficiency of, antagonism to, or abnormal dependency upon pyridoxine has been sought in four patients with primary hyperoxaluria. The urinary excretion of kynurenine, 3-hydroxykyurenineY 3-hydroxyanthranilic acid, kynurenic acid and xanthurenic acid, before and after a loading dose of L-tryptophan was used to assess pyridoxine nutrition. 2. Three of the four patients studied had ...

Neonatal Herpes simplex virus (HSV) infection is usually caused by type 2 virus following maternal peripartum genital HSV infection. Type 1 HSV usually affects infants after 3 months of age. Neonatal HSV infection present as skin, eye and mouth disease (SEM disease); affect the central nervous system (CNS disease) or involve multiple organs (Disseminated disease). Illustrative case: A full term...

In some patients without vitamin B6 deficiency, epilepsy can not be controlled without an extra supplement of vitamin B6. The therapeutic role of pyridoxal phosphate (PLP), the active form of vitamin B6, may not be replaced with other forms of vitamin B6 sometimes. Until now, four inborn errors of metabolism are known to affect vitamin B6 concentrations in the brain. Three of them are hyperprol...

The capacity of rat liver mitochondria to transport and metabolize B6 compounds has been studied. In B6-sufficient rats, 20% of the B6 content in liver is located in mitochondria. The ratio of pyridoxal-P to pyridoxamine-P in isolated mitochondria is increased with 2-oxoglutarate as substrate and decreased with glutamate. Isolated mitochondria contain pyridoxal-P(pyridoxamine-P) hydrolase activ...