OBJECTIVE To evaluate the behavioral effect of pyridoxine on the antidepressant action of imipramine. METHODS Male Wistar albino mice of weights 25-35gms were used. Two experiments were carried out; the first on the acute effect of pyridoxine on the duration of immobility, and the second on the sub-chronic effects of pyridoxine alone and in combination with imipramine. In the first experiment...

Recently we reported that the supplementation of vitamin B6 to low vitamin B6 diet caused suppression in colon tumorigenesis and cell proliferation of azoxymethane-treated mice in a dose-dependent manner among 1, 7, and 14 mg pyridoxine HCl/kg diet (J. Nutr. 131: 2204-2207, 2001). To examine the mechanism of the anticolon tumor effect of vitamin B6, male ICR mice were fed the diet containing 1,...

Pyridoxal 5'-phosphate (PLP) is the major coenzymatic form of pyridoxine. There are over one hundred known pyridoxal 5'-phosphate-dependent reactions, most of which are involved in the metabolism of various amino acids . Pyridoxamine 5'-phosphate can function in aminotransf erase reactions by the cyclic regeneration of the two active phosphate forms. Pyridoxal 5'-phosphate-dependent reactions s...

Pyridoxal phosphate is the coenzyme of various decarboxylases involved in the formation of monoamine neurotransmitters such as gamma-aminobutyric acid, serotonin, dopamine, and norepinephrine. Adult male Sprague-Dawley rats placed on a pyridoxine-deficient diet for 8 weeks showed significant hypertension compared with pyridoxine-supplemented controls. Hypothalamic contents of pyridoxal phosphat...

Coelogyne is a native Indonesian orchid with relatively large flower sizes and attractive colors. The purpose of this study was to determine the effect giving concentrations Potassium Dihydrogen Phosphate (KH2PO4) Pyridoxine in Murashige And Skoog media on growth Rochussenii De Vriese subculture. research conducted at UPT Tissue Culture Laboratory Seeds Food Crops, Horticulture, Plantation, Ria...

Pyridoxine-deficient young rats (3 weeks old) had significantly reduced levels of pituitary TSH, serum thyroxine (T4) and tri-iodothyronine (T3) compared with pyridoxine-supplemented rats. The status of the pituitary-thyroid axis of normal, pyridoxine-supplemented and pyridoxine-deficient rats was evaluated by studying the binding parameters of [3H](3-methyl-histidine2)TRH in the pituitary of t...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...