I. The Intracellular Localization of Fluorescent Convulsants. Steven E. Mayer and J. A. Bain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 11. Localization of the Hematoencephalic Barrier with Fluorescent Quaternary Acridones. Steven E. hfayer and J. A. Bain.. . . . . . . . . . . . . . . . . . . . . 17 111. The Effect of Nicotine on Synaptic Tr...

BACKGROUND The bark of Terminalia arjuna L. (Combretaceae) is used in Ayurveda since ancient times for the treatment of cardiac disorders. Previous laboratory investigations have demonstrated the use of the bark in cardiovascular complications. The present study was aimed to find the effect of 70% alcoholic extract of Terminalia arjuna on anaesthetized dog blood pressure and probable site of ac...

Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this st...

Nasal hyperresponsiveness is one of the characteristic features of the pathogenesis of allergic rhinitis. This study examined whether repetitive inhalation of antigen (Japanese cedar pollen) led to the development of nasal hyperresponsiveness to histamine in sensitized conscious guinea-pigs. Guinea-pigs were repeatedly challenged by pollen inhalation once every week following sensitization by m...

1 Organizers • IPAL (UMI CNRS, IR/A*STAR, Université Joseph Fourier), Singapore – Ludovic Roux – Daniel Racoceanu – Nicolas Loménie – Maria Kulikova – Humayun Irshad • TRIBVN Company, Châtillon, France – Jacques Klossa • Pitié-Salpêtrière Hospital, Paris, France – Prof. Frédérique Capron – Dr. Catherine Genestie – Gilles Le Naour • The Ohio State Univerity, College of Medicine, School of Biomed...

Effects of histamine (HA) and agonists of HA receptors on phosphoinositide metabolism in chick cerebral cortex have been studied using two approaches – measurement of inositol 1,4,5-trisphosphate (IP ) level by a specific and sensitive IP receptor radioassay, and analysis of [ H]inositol phosphates accumulation in cortical slices prelabeled with myo-[ H]inositol. HA concentration-dependently el...

It has long been recognized that comparatively few cases of nephritis in childhood die in the early stages of the disease and it is widely believed that the great majority of cases recover completely. Hebert (1952) has summarized the results of many of the long-term studies of nephritis in childhood published in the British and American literature in the past 30 years. In the majority of these ...

Matsumoto I, Inoue Y, Shimada T, Matsunaga T, Aikawa T. Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs. Am J Physiol Regul Integr Comp Physiol 294: R689–R698, 2008. First published January 9, 2008; doi:10.1152/ajpregu.00453.2007.—Because degranulation of brain mast cells activates adrenocortical secretion (41, 42), we exami...

Zymosan-induced peritonitis was investigated in mast cell-deficient WBB6F1 mice and in Balb/c mice pretreated with mast cell stabilizer (cromolyn) or antagonists of histamine receptors (mepyramine, triprolidine, cimetidine, or ranitidine). The inherited mast cell deficiency in W/Wv knockouts of WBB6F1 mice impaired significantly the level of histamine and plasma exudation (measured 30 min after...

The aims of the study were, in conscious Sprague-Dawley rats, to compare the effects of stresscopin-related peptide (SRP) and urocortin (UCN) 1 on blood pressure, heart rate, and regional hemodynamics; to determine whether or not there were residual tachycardic effects of SRP or UCN1 after cardiac autonomic blockade; and to investigate a possible involvement of corticotropin releasing factor ty...