نتایج جستجو برای: pyrin
تعداد نتایج: 772 فیلتر نتایج به سال:
Objectives FMF is an autosomal recessive disease, caused by mutations in the MEFV gene, encoding the pyrin protein associated with the interleukin-1b related inflammation cascade. In FMF overproduction of IL-1b and uncontrolled TNF-a release has been documented. These cytokines mediate activation of endothelial cells causing sustained inflammatory response and endothelial cell dysfunction[]. Va...
We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor mol...
References 1. The French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat Genet 1997;17:25–31. 2. The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997;90:797–807. 3. Cazeneuve C, Sarkisian T, Pecheux C, Dervichian M, Nedelec B, Reinert P, et al. MEFV-gene analysis i...
nature medicine advance online publication Despite the absence of any overt infection or definitive evidence of autoantigen-mediated immune cell activation during obesity, chronic inflammation in this state is an established instigator of several diseases such as type 2 diabetes, defective immunity, atherosclerosis, certain cancers, central nervous system dysfunction and dementia1–4. Activation...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید