نتایج جستجو برای: quantitative structureretention relationship

تعداد نتایج: 845520  

Journal: :Journal of chemical information and modeling 2006
Jaroslaw Polanski Andrzej Bak Rafal Gieleciak Tomasz Magdziarz

Quantitative Structure Activity Relationship (QSAR) is a term describing a variety of approaches that are of substantial interest for chemistry. This method can be defined as indirect molecular design by the iterative sampling of the chemical compounds space to optimize a certain property and thus indirectly design the molecular structure having this property. However, modeling the interactions...

2012
Juan C. Garro Martinez Pablo R. Duchowicz Mario R. Estrada Eduardo A. Castro

A quantitative structure activity relationship analysis was applied to a library of 51 benzylacetamide derivatives with anticonvulsant activity. The molecular structures of 51 compounds were optimized with the Semiempirical Method PM6 (Parametric Method-6) included in the MOPAC2009 software. The optimized structures of all the examined compounds were represented by 1497 DRAGON-type descriptors....

2007
FRANCISCO J. PRADO-PRADO HUMBERTO GONZÁLEZ-DÍAZ

__________________________________________________________________________________________ Abstract. There are many pathogen microbial species with very different antimicrobial drugs susceptibility. In this work, we selected pairs of antifungal drugs with similar/dissimilar species predicted-activity profile and represented it as a large network, which may be used to identify drugs with similar...

Journal: :avicenna journal of phytomedicine 0
abdorrahim absalan department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, tehran, iran seyed alireza mesbah-namin department of clinical biochemistry, faculty of medical sciences, tarbiat modares university, tehran, iran taki tiraihi department of anatomical sciences, faculty of medical sciences, tarbiat modares university, tehran, iran taher taheri shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

objective: the aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (qsar) of cinnamaldehyde and eugenol. the effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hascs) were also investigated.  materials and methods: qsar and toxicity ...

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 2013
hassan sahebjamee parichehre yaghmaei parviz abdolmaleki ali reza foroumadi

binary logistic regression (blr) has been developed as non-linear models to establish quantitative structure- activity relationships (qsar) between structural descriptors and biochemical activity of carbonic anhydrase inhibitors. using a training set consisted of 21 compounds with known ki values, the model was trained and tested to solve two-class problems as active or inactive on the basis of...

2017
Umar M. Quraishi Caroline Pont Qurat-ul Ain Raphael Flores Laura Burlot Michael Alaux Hadi Quesneville Jerome Salse

The high resolution integration of bread wheat genetic and genomic resources accumulated during the last decades offers the opportunity to unveil candidate genes driving major agronomical traits to an unprecedented scale. We combined 27 public quantitative genetic studies and four genetic maps to deliver an exhaustive consensus map consisting of 140,315 molecular markers hosting 221, 73, and 82...

2002
Peter D. Hoff

We discuss two methods of making nonparametric Bayesian inference on probability measures subject to a partial stochastic ordering. The first method involves a nonparametric prior for a measure on partially ordered latent observations, the second involves rejection sampling. Computational approaches are discussed for each method, and interpretations of prior and posterior information are discus...

2015
Ryan C. Graebner Mitchell Wise Alfonso Cuesta-Marcos Matthew Geniza Tom Blake Victoria C. Blake Joshua Butler Shiaomen Chao David J. Hole Rich Horsley Pankaj Jaiswal Don Obert Kevin P. Smith Steven Ullrich Patrick M. Hayes Guoping Zhang

The Genome-Wide Association Studies approach was used to detect Quantitative Trait Loci associated with tocochromanol concentrations using a panel of 1,466 barley accessions. All major tocochromanol types- α-, β-, δ-, γ-tocopherol and tocotrienol- were assayed. We found 13 single nucleotide polymorphisms associated with the concentration of one or more of these tocochromanol forms in barley, se...

2004
Frank Baker Reynold Bergen

Although carcass trait selection programs have primarily focused on carcass marbling (quality grade), recent changes in the North American beef industry will very likely increase the economic importance of carcass composition (yield grade). Ultrasound technology is a valuable tool in these efforts. This review summarizes recent research pertaining to the role of ultrasound in improving carcass ...

2010
Étienne Danchin Richard H. Wagner

Phenotypic variance results from variation in biological information possessed by individuals. Quantitative geneticists often strive to partition out all environmental variance to measure heritability. Behavioral biologists and ecologists however, require methods to integrate genetic and environmental components of inherited phenotypic variance in order to estimate the evolutionary potential of...

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