نتایج جستجو برای: quinazolin
تعداد نتایج: 539 فیلتر نتایج به سال:
A simple, economical and practical synthetic procedure has developed for synthesizing various 2-substituted methyl-3-substituted phenylquinazolin-4(3H)-one derivatives 4(a,b)-8(a,b) in good yields from anthranilic acid (1). The developed procedure is very effective in respect of handling, yields and economic point of view. The structural characterization of synthesized products was elucidated b...
Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, t...
In the present study, the analgesic and anti-inflammatory activities of a new alkaloid (5′-Hydroxymethyl-1′-(1,2,3,9-tetrahydro-pyrrolo [2,1-b] quinazolin-1-yl)-heptan-1-one) (compound 1), isolated from Sida cordifolia Linn. was investigated in animal models. The analgesic activity was investigated in the acetic acid induced writhing and the radiant heat tail flick model in mice a...
A novel series of (3-diethoxyphosphoryl)isoxazolidines substituted at C5 with various quinazolinones have been synthesized by the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N3-substitued 2-vinyl-3H-quinazolin-4-ones. All isoxazolidines were assessed for antiviral activity against a broad range of DNA and RNA viruses. Isoxazolidines trans-11f/cis-11f (90:10), trans-...
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