OBJECTIVE To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children. DESIGN Randomised, open label effectiveness study. SETTING Outpatient clinic of Uganda's national referral hospital in Kampala. PARTICIPANTS 175 children aged 6 to 59 months with uncomplicated malaria. INTERVENTIONS Participants were randomised to re...

The mutual inhibition between quinine and etoposide with their major metabolic pathways (i.e. quinine 3-hydroxylation and etoposide 3*-demethylation) was examined in vitro by human liver microsomes. Etoposide inhibited quinine 3-hydroxylation in a concentration-dependent manner with a mean IC50 of 65 mM. The mean maximum inhibition by etoposide (100 mM) of quinine 3-hydroxylation was about 60%....

The two stereo-isomers; quinine and quinidine have been determined in their mixtures in the IR region using chemometric multivariate methods, principal component regression (PCR) and partial least squares (PLS). A training set of thirty synthetic binary mixture solutions in the possible combinations containing 0.0 - 4.0 and 4.0 - 0.0% w/v quinine and quinidine, respectively in chloroform was us...

BACKGROUND GABAergic interneurons in the hippocampal CA1 area are mutually communicated by gap junctions (GJs) composed of connexin36 (Cx36). We examined the role of Cx36 in CA1 in manifestation of kindled seizures and hippocampal kindling in rats. METHODS Quinine, as the specific blocker of Cx36, was injected into CA1, and kindled seizures severity was examined 10 min afterward. Moreover, qu...

OBJECTIVE The aim of this study was to compare taste detection and recognition thresholds of young males and females, and young phenylthiocarbamide (PTC) "tasters" and "nontasters" for stimuli representing sweet, sour, bitter, salty, and umami classes of taste sensations. STUDY DESIGN Thirty-eight men and 37 women (mean [SD] age = 24.5 [2.5] years) were classified as PTC tasters and nontaster...

BACKGROUND In children with falciparum malaria, a proprietary quinine preparation (adjusted to make it less acidic) administered rectally may be easier to use and less painful than intramuscular or intravenous administration. However, rectal quinine may be less effective. OBJECTIVES To compare intrarectal quinine with intravenous or intramuscular quinine for treating malaria caused by Plasmod...

Intraduodenal quinine, in the dose of 600 mg, stimulates glucagon-like peptide-1 (GLP-1), cholecystokinin and insulin; slows gastric emptying (GE); lowers post-meal glucose men. Oral sensitivity to bitter substances may be greater women than We, accordingly, evaluated dose-related effects quinine on GE, glycaemic responses to, a mixed-nutrient drink females, compared higher with those males. A ...

to buy it. An efficient and trustworthy substitute for quinine which could be produced cheaply in any well-equipped chemical factory would be of enormous benefit to mankind. Already several preparations have been put on the market as substitutes for the cinchona alkaloids, but they have proved useless. Chemists have tried for years to make a synthetic quinine, and recently a substance, closely ...

Sir,?I have read the questions column of the July issue of the Indian Medical Gazette for treatment of malaria with interest. I am using as a routine quinine mixture (10 grains of quinine sulphate in 3 oz. of water per day) or quinarsol (Cipla) one tablet twice a day for the first two days along with the regular course of paludrine tablets, viz, 0.3 gm. twice a day for 10 days. The action of pa...

Sixty-six children presenting to Singa hospital, Sudan with different manifestations of severe Plasmodium falciparum malaria were randomly divided into two well-matched groups (33 in each arm) to receive either intravenous artesunate 2·4 mg/kg at 0, 12, and 24 hours, then daily, or intravenous quinine 20mg/kg initially then 10mg/kg three times a day. There was no significant difference in the f...