OBJECTIVE The relationship between circulating markers of inflammation and arterial stiffness in children with type 1 diabetes is not well studied. We tested whether inflammatory monocyte chemoattractant protein (MCP)-1 concentrations correlate with arterial stiffness or type 1 diabetes status. RESEARCH DESIGN AND METHODS MCP-1 concentrations and radial tonometry data were available for 98 ch...

Young African-American men have altered macrovascular and microvascular function. In this cross-sectional study, we tested the hypothesis that vascular dysfunction in young African-American men would contribute to greater central blood pressure (BP) compared with young white men. Fifty-five young (23 yr), healthy men (25 African-American and 30 white) underwent measures of vascular structure an...

RATIONALE Chronic obstructive pulmonary disease (COPD) is associated with a 2-3-fold increase in the risk of ischaemic heart disease, stroke and sudden death. The mechanisms responsible for this association are not clear and appear to be independent of smoking history. OBJECTIVE We test the hypothesis that patients with COPD have increased arterial stiffness and blood pressure in comparison w...

OBJECTIVES The goal of this study was to investigate the relation between serum cholesterol, arterial stiffness and central blood pressure. BACKGROUND Arterial stiffness and pulse pressure are important determinants of cardiovascular risk. However, the effect of hypercholesterolemia on arterial stiffness is controversial, and central pulse pressure has not been previously investigated. METH...

When humans rotate their wrist in flexion-extension, radial-ulnar deviation, and combinations, the resulting paths (like the path of a laser pointer on a screen) exhibit a distinctive pattern of curvature. In this report we show that the passive stiffness of the wrist is sufficient to account for this pattern. Simulating the dynamics of wrist rotations using a demonstrably realistic model under...

PURPOSE Several studies have shown arterial stiffness changes associated with coronary artery disease (CAD). Recently, statins were reported to improve arterial stiffness. The aim of the study was to evaluate the effect of atorvastatin on arterial stiffness in CAD patients using pulse wave velocity (PWV). METHODS We evaluated 63 patients with hyperlipemia and CAD. Forty-three patients were gi...

Existing methods for structural health monitoring pose a formidable challenge to real time implementation due to the significantly large computational loads. The proposed algorithm is suitable for online applications because it maintains good pattern recognition capabilities while possessing a computationally compact network topology. This study employs the computational efficiency of single la...

OBJECTIVE The relationship between increased arterial stiffness and cardiovascular mortality is well established in type 2 diabetes. We examined whether aerobic exercise could reduce arterial stiffness in older adults with type 2 diabetes complicated by comorbid hypertension and hyperlipidemia. RESEARCH DESIGN AND METHODS A total of 36 older adults (mean age 71.4 +/- 0.7 years) with diet-contro...

BACKGROUND Outside pregnancy, arterial pulse wave analysis provides valuable information in hypertension and vascular disease. Studies in pregnancy using this technique show that vascular stiffness is raised in women with established pre-eclampsia. We aimed to establish normal ranges for parameters of pulse wave analysis in normal pregnancy and to compare different ethnic groups. METHODOLOGY/...