INTRODUCTION Radioactive iodine (RAI) therapy may induce or worsen orbitopathy (GO) in Graves' disease (GD). The aim of this study was a prospective assessment of the risk of GO exacerbation in a GD patients cohort submitted to RAI therapy for hyperthyroidism. MATERIAL AND METHODS 208 consecutive GD patients treated with 131I in 2007 were enrolled. The analysis was performed on 156 patients s...

Preparation for radioactive iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a low iodine diet (LID). Because of extremely high iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period ...

The purpose of this review is to discuss the various means by which iodine ingestion through dietary intake or therapeutic administration can influence the pathogenesis, prevalence, presentation or outcome of differentiated thyroid cancer (DTC). The relationship between iodine nutrition and DTC pathogenesis is complex, arising from the fundamental observation that anything that stimulates thyro...

background: this study aimed to assess several biochemical and oxidative stress parameters before and after radioiodine therapy in patients with well-differentiated thyroid cancer who consumed a low iodine diet and withdrawal of levothyroxine after total thyroidectomy. methods: we enrolled 40 candidates for radioiodine therapy. blood sampling was performed prior to as well as 72 h after consump...

The major fallout of radionuclides from the nuclear power station accident at Chernobyl on 26 April, 1986, occurred in regions of Ukraine and Belarus that are believed to be moderately deficient in dietary iodine. On 17 November, 2000, in conjunction with the Ukraine-Belarus-USA study of developing thyroid disease in a cohort of individuals exposed as children, a workshop was held to review wha...

OBJECTIVE Current diagnosis of radioactive iodine (RAI)-refractory (RAIR) differentiated thyroid cancer (DTC) is based on the imaging technique, which is of a high cost. Serum thyroglobulin (Tg) is a sensitive and easily obtained biomarker. Hence, we aimed to assess the predicting value of quantitative response of Tg in earlier identifying the RAIR-DTC with pulmonary metastasis. PATIENTS AND ...

Iodine has always been connected to thyroid gland, and the fact that thyroid tissue traps, organificates and stores iodine more than other tissues is well known, hence the use of radioiodine as a diagnostic and therapeutic tool for thyroid disorders. However, false-positive cases do occur. We present a case of a 34-year-old patient who underwent total thyroidectomy for papillary carcinoma. Resu...

MEASUREMENT of the ankle reflex time by means of a kinemometer has been shown to be a useful aid in the clinical diagnosis of hypothyroidism (Abraham, Atkinson, and Roscoe, 1966). It is not known whether it will also serve as a screeing procedure for this disorder. In the Birmingham region a follow-up system has recently been initiated to effect the continued surveillance of thyrotoxic patients...

The T-1824 dye method for plasma volume measurement has been subjected to much criticism. The validity of its use as a tagged protein dilution method has been questioned. One of the major criticisms has been that part of the injected dye is rapidly removed from the plasma before binding with protein occurs. This objection does not apply to the use of human serum albumin tagged with radioactive ...

The value of radioactive iodine (I131) in the investigation of disorders of the thyroid gland is now well recognized (Pochin, 1950; Myant, 1952; Wayne, 1954). While 1131 has been used more frequently in adults than in children, its application to the study of abnormalities of thyroid function has added considerably to our understanding of the varied aetiology and pathogenesis of hypothyroidism ...