By using stereospecifically double-labelled radioactive mevalonates it was shown that betulaprenols-6 to -9, found in the woody tissue of Betula verrucosa, each contain three biogenetically trans-isoprene residues and that the remaining residues are biogenetically cis. The results obtained with these radioactive mevalonates also indicated that the activity of isopentenyl pyrophosphate isomerase...

One of the best procedures to prevent haemarthrosis in haemophilia has been radioactive synovectomy (radiosynoviorthesis). Since 1976 we have performed 119 radiosynoviortheses in 110 patients, aged from 3 to 40 years (mean 10), and of whom 71 were under 12 years of age. The knees were injected in 71, elbow in 29, ankles in 16, and shoulders in 3 cases. Clinical results of the procedure gave exc...

Aberrant expression of the sodium-iodide symporter (NIS) and the resistance to post-operative radioactive iodide treatment is a crucial cause of higher mortality of some thyroid cancer patients. In this study, we analyzed the impact of miR-146a on the expression and function of NIS and on the overall survival of thyroid cancer patients. The study included 2441 patients (2163 women; 278 men); in...

BACKGROUND Radioactive stents have been reported to reduce in-stent neointimal thickening. An unexpected increase in neointimal response was observed, however, at the stent-to-artery transitions, the so-called "edge effect." To investigate the factors involved in this edge effect, we studied stents with 1 radioactive half and 1 regular nonradioactive half, thereby creating a midstent radioactiv...

Nuclear Medicine (NM) is a medical imaging technique in which patients are administered radioactive tracers. As the tracers decay in the human body, they emit photons, which are then captured to generate an image used for diagnostic purposes. The schedule of daily patients in an NM center is a hard and interesting problem due to the continuous decay of these radioactive tracers. This scheduling...

The usefulness of the various tests of thyroid function has been evaluated over a three-year period. It is concluded that an uptake test and estimation of the serum protein-bound radioactive iodine (PB (131)I), supplemented as required by the protein-bound iodine (PBI), remain the best routine tests of thyroid function. Forty-five patients who gave discordant results on these tests over this pe...

Although there are a number of reports concerning the uptake of various radioactive nuclides from surrounding water by aquatic organisms1), the quantitative informations on the transfer of radioactive substances through aquatic food chains have been scarcely obtained until now. In near future, in accordance with the rapid developement of the peaceful utilization of atomic energy in Japan, the p...

THE SUCCESSFl'L application of radioactive indicators in physiology caused the early introduction of a radioactive component into the erythrocytes and their use in blood volume determinations. While this method has found application in animal experiments, it is not very suitable for determination of the blood volume of humans, since ironlabeled red corpuscles can only be obtained in vivo, and t...

RADIOACTIVE iodine (iodine-131) has been used extensively during the past 30 years for the treatment of hyperthyroidism and has been shown to control this disorder in the majority of cases in which it has been used. There have been varying reports of the incidence of post-radiation hypothyroidism which has been reported to be as high as 70 per cent in patients followed up for 10 years (Beling a...