MULTIPLE SCLEROSIS MSJ JOURNAL With the increasing use of brain magnetic resonance imaging (MRI) by clinicians, researchers and even companies that carry out health checkups the finding of asymptomatic intracranial abnormalities of potential clinical significance has risen tremendously. 1 In a recent meta-analysis, the prevalence of neoplastic and non-neoplastic incidental findings on brain MRI...

OBJECTIVE To improve the characterization of asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a condition named as "radiologically isolated syndrome" (RIS). METHODS Quantitative MRI metrics such as brain volumes and magnetization transfer (MT) were assessed in 19 subjects previously classified as RIS, 20 demographica...

BACKGROUND The discovery and broad application of MRI in medicine has led to an increased awareness in the number of patients with incidental white matter pathology in the CNS. Routinely encountered in clinical practice, the natural history or evolution of such individuals with respect to their risk of developing multiple sclerosis (MS) is unclear. OBJECTIVE To investigate the natural history...

background:  multiple sclerosis (ms) is a chronic inflammatory and demyelinating disease of the central nervous system, which is accompanied by significant disabilities. although there are some published data regarding the epidemiological features of ms in other parts of iran, scarce data are available about the prevalence and demographic characteristics of ms in fars province. the current stud...

vitamin d has long been speculated to reduce the risk of multiple sclerosis (ms). however, its role in development and modulating the course of ms has yet to be clarified. to date, there is no scientific evidence for the use of vitamin d as monotherapy for ms in clinical practice and perplexities still exist on potential disadvantages of vitamin d intake. we hypothesize that vitamin d may be ef...

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background: little in known regarding the clinical relevance of sirt1 in multiple sclerosis (ms).   here, we aimed to evaluate mrna expression, protein level and enzyme activity of sirt1 in peripheral blood mononuclear cells (pbmcs) isolated from relapsing –remitting ms patients (rrms) and healthy controls. materials and methods: twenty patients with rr-ms and twenty two age- and sex-matched he...

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

background: there has been a global rising trend in recent years in the incidence of multiple sclerosis (ms). despite being an ms low-risk region, this disease has also been recently on the rise in the middle east. as part of the middle east, iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. the present study reviews possible reasons for thi...