Angiotensin I-converting enzyme (ACE) inhibitors can affect hematopoiesis by several mechanisms including inhibition of angiotensin II formation and increasing plasma concentrations of AcSDKP (acetyl-N-Ser-Asp-Lys-Pro), an ACE substrate and a negative regulator of hematopoiesis. We tested whether ACE inhibition could decrease the hematopoietic toxicity of lethal or sublethal irradiation protoco...

The development of radioprotective agents has been a subject of intense research in view of their potential for use within a radiation environment, such as space exploration, radiotherapy and even nuclear war. Since no ideal, safe synthetic radioprotectors are available to date, the search for alternative sources, including plants, has been on-going for several decades. In the Traditional India...

The physiologic role of CXCR4 on hematopoietic stem/progenitor cells (HSPCs) is not fully understood. Here, we show that radioprotection of lethally irradiated mice by embryonic day 14.5 (E14.5) CXCR4 / fetal liver (FL) cells was markedly impaired when compared with CXCR4 / counterparts, but this defect was rescued when hosts were engrafted with high cell numbers. This quantitative defect contr...

background: to evaluate the radioprotective potential of punica granatum fruit rind extract (pgre) in mouse testes. materials and methods: adult male mice were divided into four groups. group i was kept without any treatment. group ii was irradiated with 8gy co60 gamma irradiation and group iii was given pgre one hour before irradiation. group iv was fed with pgre at the rate of 10 mg/kg body w...

the protective effects of rheum tanguticum polysaccharide 1 (rtp1), which is extracted from the chinese traditional medicine rheum tanguticum, on radiation-induced intestinal mucosal injury was investigated. rat intestinal crypt epithelial cells (iec-6 cells) and sprague-dawley rats were each divided into control, irradiated and rtp1-pretreated irradiated groups. after irradiation, cell surviva...

Cette étude, réalisée par l’IRSN (Institut de Radioprotection et Sûreté Nucléaire) dans le cadre d’une demande l’ASN (Autorité Nucléaire), concerne la caractérisation des formes physico-chimiques composés radioactifs rejetés les installations françaises fabrication radiopharmaceutiques au moyen d’un cyclotron. Elle vise à disposer meilleure connaissance sur effluents gazeux ces installations. é...