Very little is known concerning the changes that occur in living tissue following the injection of solutions of an “active deposit’’ of radium emanation. This investigation was undertaken to determine what changes occur in the principal organs of the animal body following such a treatment, and to afford data that might act as a guide in the treatment of certain types of cancer, in which the sol...

In 2004, docetaxel was approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC). For the next several years, there was a lull in drug approvals. However, from 2010 onwards, 5 additional therapies have been approved on the basis of showing a survival benefit in phase III studies. These agents include sipuleucel-T, cabazitaxel, abiraterone, enzalutamide and (most rece...

The purpose of this study was to identify the existence of Relative Age Effect (RAE) at youth level in both elite and amateur Spanish soccer clubs, and also to carry out an analysis providing with information on how this effect has evolved in recent years. We have obtained information on the youth teams of the 20 clubs belonging to the Spanish Professional Football League (LFP) in two separate ...

Whereas those working on the inside of tourism generally feel that tourism research is making good progress, the 2001 Research Assessment Exercise (RAE) in the UK offered an outsiders' assessment of UK tourism research that was less benign. This paper examines the results and consequences of the RAE based on an examination of the submissions made by UK higher education institutions. It describe...

The relative age effect (RAE) is a biased distribution of elite athletes' birthdates, with an overrepresentation of those born at the beginning of the competitive year and an underrepresentation of those born at the end. Despite an abundant literature, the impact of sex on this phenomenon remains neglected by most researchers. This study investigated the whole sample of female soccer players af...

Researchers who study the relative age effect (RAE) have stated that, within a given cohort, individuals who are relatively older tend to be over-represented at elite levels within sport. This RAE has been illustrated in hockey, soccer, and baseball, to name a few. Recently, Baker and Logan conducted an analysis on the birth dates of players drafted to the National Hockey League (NHL) between 2...

The relative age effect (RAE) is considered a common phenomenon in elite sport. Howeven it has not been examined systematically in previous research, and the mechanisms likely to generate or to limit such an effect are little understood. This paper investigates the prevalence of the RAE in French professional championship-level players, taking into account the potential influence of gender. Amo...

Radium isotopes (Ra, Ra, Ra, and Ra) and water chemistry were used to identify two chemically distinct sources of submarine groundwater discharge (SGD) in Celestún Lagoon, Yucatán, Mexico. Low salinity groundwater discharging from springs within the lagoon has previously been identified and extensively sampled for nutrient concentrations. However, a second type of groundwater discharging into t...

Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo®) is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichlorid...

A 20 year quantitative assessment of research in British universities has coincided with a renaissance in their international status. But even as other nations seek to emulate the approach, domestic critics are calling into question its dominance over university life.