Raman spectroscopy was used to study the time course of phenotypic responses of Escherichia coli (DH5α) to 1-butanol exposure (1.2% [vol/vol]). Raman spectroscopy is of interest for bacterial phenotyping because it can be performed (i) in near real time, (ii) with minimal sample preparation (label-free), and (iii) with minimal spectral interference from water. Traditional off-line analytical me...

We discuss the novel design of a sensitive, normal-Raman spectrometer interfaced to an ultra-high vacuum chamber (5 × 10(-11) Torr) utilized to investigate the interaction of ionizing radiation with low temperature ices relevant to the solar system and interstellar medium. The design is based on a pulsed Nd:YAG laser which takes advantage of gating techniques to isolate the scattered Raman sign...

BACKGROUND Several changes occur during the transformation of normal tissue to neoplastic tissue. Such changes in molecular composition can be detected by Raman spectroscopy. Raman spectroscopy is a nondestructive method of measuring these changes, which suggests the possibility of real-time diagnosis during medical procedures. METHODS This study seeks to evaluate the ability of Raman spectra...

We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm-1) and high-wavenumber (HW) (i.e., 2800-3600 cm-1) fiber-optic Raman spectroscopy developed for real-time in vivo diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality in vivo FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; canc...

Coronary intravascular ultrasound (IVUS) can assess arterial wall architecture and localize large intravascular deposits, but it does not provide quantitative chemical information, which is essential in the evaluation of atherosclerotic lesions. Previously, it has been shown that Raman spectroscopy can be used to accurately quantify the relative weights of cholesterol, calcium salts, triglyceri...

This review covers the development of understanding of polymer morphology of fibrous polymers using Raman Spectroscopy. Morphology refers to form and structure that a polymer exhibit and is influenced by the local microstructure of the back-bone chain. In chain like polymer molecules, the vibration of the carbon chain is easily studied by using Raman spectroscopy. The utility of this technique ...

The rupture of vulnerable atherosclerotic plaque accounts for the majority of clinically significant acute cardiovascular events. Because stability of these culprit lesions is directly related to chemical and morphological composition, Raman spectroscopy may be a useful technique for their study. Recent developments in optical fiber probe technology have allowed for the real-time in vivo Raman ...

Introduction Raman spectroscopy is one of the most common techniques for materials identification and characterization. Based on inelastic scattering of a monochromatic excitation source, Raman measures vibrational, rotational and other low-frequency modes in a system. It’s not only characteristic for functional groups, but also sensitive to backbone and crystalline structures. Therefore, Raman...

We report on the development of a novel multiplexing Raman spectroscopy technique using a single laser light together with a volume phase holographic (VPH) grating that simultaneously acquires both fingerprint (FP) and high wavenumber (HW) tissue Raman spectra at endoscopy. We utilize a customized VPH dual-transmission grating, which disperses the incident Raman scattered light vertically onto ...

Citation: Lupoi JS, Fritz LP, Parris TM, Hackley PC, Solotky L, Eble CF and Schlaegle S (2017) Assessment of Thermal Maturity Trends in Devonian–Mississippian Source Rocks Using Raman Spectroscopy: Limitations of Peak-Fitting Method. Front. Energy Res. 5:24. doi: 10.3389/fenrg.2017.00024 assessment of Thermal Maturity Trends in Devonian–Mississippian source rocks Using raman spectroscopy: limit...