Background Prior observational studies indicate that lower systolic blood pressure (SBP) after successful endovascular treatment (EVT) is associated with better functional outcomes in patients acute ischemic stroke. However, whether targeting SBP to levels below the guideline‐recommended target of ≤180 mm Hg safe and efficacious remains be determined. Methods The BEST (Blood Pressure After Endo...

Level 1 Evidence Level 1 evidence can come in one of 2 forms: a randomized clinical trial, which is associated with low study errors (low P value, confidence interval which excludes 1, or a ‘‘negative’’ result associated with a power of over 80%), or a meta-analysis. A meta-analysis refers to a study that statistically synthesizes the results of numerous ‘‘underpowered’’ randomized clinical tri...

T HE RANDOMIZED CLINICAL TRIAL IS THE GOLD standard for evaluating a therapy, providing the highest evidence for the practice of evidence-based medicine. However, not all randomized clinical trials are informative and the success of the trial in demonstrating a valid treatment or diagnostic effect will depend on the elements of the study design. The purpose of this report is to highlight the es...