Crescentic glomerulonephritis is characterized by extracapillary proliferation resulting from severe inflammatory injury of various aetiologies. It is usually rapidly progressive. Meanwhile, anti-glomerular basement membrane (GBM) antibody-mediated glomerular lesions induce crescentic glomerulonephritis. When associated with pulmonary haemorrhage, it is given the eponym 'Goodpasture's syndrome'...

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immuno...

We report a case of a 71-year-old man with rapidly progressive nephritic syndrome and dual positivity for anti-glomerular basement membrane antibody and myeloperoxidase-specific anti-neutrophil cytoplasmic antibody. Renal biopsy revealed crescentic, mainly cellular, glomerulonephritis with granulomatous lesions, and advanced membranous changes. Membranous nephropathy had apparently existed for ...

Two cases of lung granulomata associated with "crescentic" glomerulonephritis both in a clinical setting of polyarteritis nodosa were treated with high doses of intravenous methylprednisolone ("pulse therapy") in single injections of 30 mg/kg body-weight. In the first case rapidly progressive glomerulonephritis with 100% crescents was arrested and followed by improvement of renal function from ...

Goodpasture’s syndrome is a rare, life-threatening pulmonary-renal syndrome characterized by the production of autoantibodies to a component of the glomerular basement membrane (GBM). The syndrome involves an autoimmune response to the non-collagen domain 1 of the human alpha-3 chain of type IV collagen, α3(IV)NC1. The term Goodpasture’s syndrome is often used to refer to the constellation of a...

We report a 42-year-old man with subacute infectious endocarditis (IE) with septic pulmonary embolism, presenting rapidly progressive glomerulonephritis and positive proteinase 3-anti-neutrophil cytoplasmic antibody (PR3-ANCA). He had no previous history of heart disease. Renal histology revealed diffuse endocapillary proliferative glomerulonephritis with complement 3- (C3-) dominant staining a...

background: sub-acute bacterial endocarditis (sbe) rarely presents with features of a small vessel vasculitis. patients with sbe can also develop multiple serological abnormalities including anca. in this report, we present a case of infective endocarditis mimicked anca associated glomerulonephritis.case presentation: a 57-year old male with a clinical picture of rapidly progressive renal failu...