نتایج جستجو برای: rare bleeding disorders
تعداد نتایج: 934255 فیلتر نتایج به سال:
Coagulation disorders concern a deficiency of the body’s functional ability to regulate blood clotting (Peyvandi and Mannucci, 1999). Disorders in thisarea, which may be genetic or acquired, will result in hemostasis-related problems, including different clinical syndromes from easy bleeding or bruising (so-called “hemophilia”) to inappropriate thrombosis (so-called “thrombophilia”; Weisberg, 1...
oral surgery in patients with bleeding disorders is associated with a high risk of bleeding during and after surgery. this article is aimed to present the case of an eight-year-old girl suffering from severe fanconi anemia with pancytopenia who underwent a dental extraction. the hemostatic effect of local administration of tranexamic acid in combination with a primary suture seems to be extreme...
Abstract Cyclic thrombocytopenia (CTP) is a rare disease, which characterized by periodic fluctuation of the platelet count. The pathogenesis CTP unknown and most likely heterogeneous. Patients with are almost always misdiagnosed as having primary immune (ITP). interval between ITP diagnosis can be many years. patients often receive ITP-specific therapies including corticosteroids, thrombopoiet...
Congenital factor X deficiency is a rare autosomal recessive bleeding disorder that presents with variable bleeding tendency and prolonged coagulation tests, prothrombin time, and partial thromboplastin time. Thromboembolic events have not been reported in patients with factor X deficiency yet. Herein, we report a patient with factor X deficiency who had recurrent venous thromboembolic events.
Inherited platelet disorders are a heterogeneous group of rare diseases, caused by inherited defects in platelet production and/or function. Their genetic diagnosis would benefit clinical care, prognosis and preventative treatments. Until recently, this diagnosis has usually been performed via Sanger sequencing of a limited number of candidate genes. High-throughput sequencing is revolutionizin...
Subdural hematoma (SDH) is a rare complication of immune thrombocytopenic purpura (ITP) the incidence being around 2%. Although SDH usually occurs secondary to trauma, in bleeding disorders it may occur spontaneously. Here we report subdural hematoma in two uncommon settings, one patient with systemic sclerosis developing secondary ITP and consequently subdural hematoma and the other patient wi...
Invasive fungal infections have turned out to be a significant cause of morbidity and mortality in pediatric patients with malignant disorders. Massive hemoptysis, a rare complication of invasive pulmonary aspergillosis, may threaten the lives of patients, usually during the resolution of neutropenia. In this report, we describe a patient with massive hemoptysis due to invasive pulmonary asperg...
Acquired Hemophilia A (AHA) is a rare bleeding diathesis characterized by the development of autoantibodies against factor VIII (FVIII). About half of the cases are idiopathic and the other half are associated with autoimmune diseases, postpartum problems, infections, inflammatory bowel disease, drugs, lymphoproliferative disorders or solid tumors . AHA is associated with malignancies in 7-15% ...
INTRODUCTION Management of haemophilia and inherited bleeding disorders is a major challenge especially in developing countries, because of a shortage or absence of products, the cost and the infrastructural health problems. Development of local expertise which results in an improved outlook and reduction in mortality and morbidity in these countries can be helpful for advocators in other devel...
Additional therapeutic options are needed for patients with bleeding disorders such as hemophilia A, hemophilia B, severe von Willebrand disease, and other rare factor deficiencies. A novel approach to improve coagulation in such clotting disorders has been identified that, parodoxically, involves heparinlike sulfated polysaccharides. Select molecules of this broad class are largely devoid of a...
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