Cytochrome P-450 was purified to apparent homogeneity from the brain microsomes of phenobarbital-treated rats. The specific content of the purified P-450 was 12.7 nmol/mg of protein. NADPH-cytochrome P-450 reductase (reductase) was also purified to apparent homogeneity from brain microsomes. The specific content was 34.7,mol of cytochrome c reduced/min per mg of protein. The reduced carbon mono...

Objective: Phthalates, despite their endocrine disrupting effects, are widely used as plastifiants. Environmental exposure of phthalates was demonstrated to cause fetal death and reproductive toxicity in human beings, well laboratory animals. However, underlying mechanisms not clear.
 Material Methods: Here, we examine the impact di(2-ethylhexyl) phthalate (DEHP) dibutyl (DBP)on rat lungs,...

The aim of the present work was to assess the effects of activation of NMDA receptors in rat brain in vivo on calcium homeostasis in isolated non-synaptic brain mitochondria. We have shown recently that acute intoxication with large doses of ammonia leads to activation of NMDA receptors in rat brain in vivo. In the present work we injected rats with ammonium acetate to activate NMDA receptors i...

Disruption of blood-brain barrier is a common brain injury in intracerebral hemorrhage. Sufentanil an analogue fentanyl, and acts as opioid analgesic postsurgical analgesia anaesthesia. also exerted neuroprotective effect against cerebral infarction. The role sufentanil hemorrhage (ICH)-induced was investigated. Firstly rat model established by local injection collagenase IV into striatum. Rats...

Increasing attention is being paid to alterations of the hemostatic balance in tumors, in general, and brain tumors, in particular. Apparently divergent results, showing excess fibrinolysis (i.e., increased plasminogen activator activity) or its inhibition (i.e., increased inhibitor activity), have been reported. The 9L rat brain tumor is a gliosarcoma and a model used to study treatment paradi...

Thioltransferase (TTase) is a member of the family of thiol-disulfide oxidoreductases that are involved in the maintenance of sulfhydryl homeostasis in cells by catalyzing thiol-disulfide interchange reactions. One of the major consequences of oxidative stress in brain is the formation of protein-glutathione mixed disulfides (through oxidation of protein thiols), which can be reversed by TTase ...

The purified Na+ channel from rat brain consists of a (260 kDa), Bl (36 kDa), and ,192 (33 kDa) subunits. Pure ,t?l subunits were prepared from purified rat brain Na+ channels which had been adsorbed to hydroxylapatite resin and used to prepare specific anti-81 subunit antiserum. Antibodies purified from this antiserum by antigen affinity chromatography immunoprecipitate 12SI-labeled, purified ...

Multivariate processes with long-range dependence properties can be encountered in many fields of application. Two fundamental characteristics such frameworks are parameters and correlations between component time series. We consider multivariate dependent linear processes, not necessarily Gaussian. show that the covariances wavelet coefficients this setting asymptotically also study asymptotic...

The brain produces various reactive oxygen species in enzymatic and non-enzymatic reactions as a by-product of metabolism and/or for redox signaling. Effective antioxidant system the cells maintains balance. However, neurons glia from some regions are more vulnerable to oxidative stress ischemia/reperfusion, epilepsy, neurodegenerative disorders than rest brain. Using fluorescent indicators liv...