COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play key role in adaptive antiviral immune response killing infected and facilitating selection of virus-specific antibodies. However, neither dynamics cross-reactivity SARS-CoV-2-specific T-cell nor diversity resulting memory well understood. In this study, we use longitudinal high-throughput receptor (TCR) sequencing ...

Symbiosis Group Figure 1: Three different mechanisms of ADE (Antibody-dependent enhancement): A-receptors on virus particles bound by cross-reactive antibody get conformational change in structure that results in high affinity with the corresponding receptor on the host cell membrane. The corresponding receptor was not able to recognize the viral receptor before this conformational change. BThe...

The finding of large granular cells is relatively frequent when reviewing a blood smear for lymphocytosis (or any other reason). presence these opens the question as if they are part T-cell non-clonal reactive process or indicate clonal population (yet not necessarily neoplastic).

The article shows the antioxidant properties of new derivatives 2-aminothiazole containing diterpene fragment. Using method luminol-dependent chemiluminescent analysis it is revealed that tested compounds under investigation exhibit in model test systems, where processes reactive oxygen species formation, lipid peroxidation, and cell phagocytosis blood are induced.

Background: Immunophenotyping in the rare group of nodal Peripheral T-cell Lymphomas (PTCL) exposes interesting features such as T-cell marker downregulation and paradoxically, the presence of reactive, clustered large-sized CD20 positive B-cells (B-cell proliferation). Epstein-Barr virus (EBV) has been suggested as a putative etiology in pathogenesis of B-cell lymphoma. We aimed to review the ...

We pursue an analytical approach to energy consumption characterization of large scale mobile ad hoc networks. An energy aware hybrid routing strategy is proposed and analyzed. Referred to as Energy Aware GEo-location aided Routing (EAGER), this protocol optimally blends proactive and reactive routing strategies for energy efficiency. Specifically, EAGER partitions the network into cells and pe...

bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

autoimmune hemolytic anemia (aiha) is characterized by shortening of red blood cell (rbc) survival and the presence of autoantibodies directed against autologous rbcs. approximately 20% of autoimmune hemolytic anemia cases are associated with cold-reactive antibody. about half of patients with aiha have no underlying associated disease; these cases are termed primary or idiopathic. secondary ca...

sepsis is a significant health problem with an estimated 750,000 new cases in the usa annually. it is also the third leading cause of death in developed countries, equaling the number of fatalities from acute myocardial infarction. the high sepsis-related mortalities mean there is an urgent need to improve the diagnosis and management of sepsis patients. the aim of this study was the evaluation...