background and objectives: coronary artery disease (cad) is regarded as the leading cause of morbidity and mortality around the world. diabetes mellitus (dm) is associated with the development of cad and increased risk of morbidity and mortality. the goal of this study was to assess the association of tumor necrosis factorα (tnf-α) and high sensitivity c-reactive protein (hscrp) with cad severi...

background: in most of the studies, the association of vascular events is limited to migraine with aura or it is stronger in this group, whereas the link between migraine without aura (mo) and vascular events remained uncertain. therefore, we decided to evaluate endothelial function by chemical and functional markers of endothelium in mo and compare with normal population. methods: in this stud...

background selenium deficiency is a common problem in patients with chronic kidney disease (ckd). this micronutrient has anti-inflammatory and anti-oxidant effects. selenium is also found in high concentrations in the thyroid gland. objectives to determine the effect of selenium supplementation on thyroid function tests and acute phase reactants in hemodialysis patients. patients and methods in...

background patients with systemic lupus erythematous (sle) are more prone to atherosclerosis and cardiovascular diseases due to atherosclerosis and consequently death. objectives the aim of this study was to explore a possible relationship between the intima media thickness (imt) of carotid arteries and the levels of c-reactive protein (crp) in sle patients. patients and methods: sixty sle pati...

Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

Background Biased G protein-coupled receptor (GPCR) ligands preferentially activate protein- or β-arrestin signaling pathways and are leading to the development of drugs with superior efficacy reduced side-effects in heart disease, pain management, neuropsychiatric disorders. Although GPCRs implicated pathophysiology Alzheimer’s disease (AD), biased GPCR is an unexplored area investigation AD. ...

Reactive oxygen species serve as second messengers for signal transduction; however, molecular targets of oxidant signaling have not been defined. Here, we show that ligand-receptor-mediated signaling promotes reactive oxygen species-dependent protein carbonylation. Treatment of pulmonary artery smooth muscle cells with endothelin-1 increased protein carbonyls. Carbonylation of the majority of ...

Introduction: Coronary artery disease (CAD) is among the most common, serious, chronic and life- threatening illnesses in the world. CAD represents a spectrum of conditions, with acute myocardial infarction at one end of it and silent ischemia at the other. There is growing evidence on importance of prognosis of C- reactive protein (CPR) in unstable angina and this protein is a maker of an adve...

programmed cell death-1 (pd-1) and its ligands, pd-l1 and pd-l2, have been regarded as important immune system regulatory molecules. the aberrant expression of the molecules has been related to several autoimmune disorders. this study is aimed to assess the mrna expression level of pd-1, pd-l1, and pd-l2 molecules in the peripheral blood mononuclear mells (pbmcs) from multiple sclerosis (ms) pa...