objective:  to assess whether non-surgical periodontal treatment is associated with changes in serological markers of systemic inflammation. materials and methods: thirty-five systemically healthy subjects with severe generalized periodontitis meeting the inclusion criteria participated in a four-month single blind interventional trial of which thirty-two completed the study. periodontal parame...

background: increased serum high sensitive c-reactive protein (hs-crp) in asthma and its association with disease severity has been investigated in many studies. this study aimed to determine serum hs-crp status in asthma versus healthy controls and to examine its ability in predicting asthma control. methods: serum crp was measured by elisa method using a high sensitive crp kit. severity of as...

introduction : surgical removal of inferior third molar tooth is associated with post-operative complications such as pain, trismus and edema. decreasing the post-operative inflammation and edema is one of the important goals in drug administration. for management of post-operative pain, nonsteroidal anti-inflammatory drugs (nsaids) and opioids can be administered. c-reactive protein (crp) is o...

background & objective: there are many common infections and inflammations among people over the world. this demands an affordable and reliable test with high sensitivity/specificity to predict or confirm the diagnosis of such cases in routinely clinical practice. in the present study, we aimed to find any potential correlation between serum levels of ggt and crp- q and/or hs- crp and wbc c...

coronary heart disease is the leading cause of death and disability in adults. the association between acute coronary syndrom (acs) and elevated serum high sensitivity c-reactive protein (hscrp) suggests that chronic inflammation of the coronary arterial wall may play an important role. a number of drugs used in the treatment of cardiovascular disease reduce serum crp. it* is therefore possible...

INTRODUCTION The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context of the sepsis syndrome. The aims of this study were to assess the impact of MG formation in different inflammatory settings and to evaluate its use for early diagnosis as well as prognosis of the sepsis syndrome. METHODS In total, 120 patients in three groups were enrolled in...

Gram-negative bacteremia has been associated with severe sepsis, although the exact mechanism and pathophysiological differences among bacterial species are not well understood. In the previous issue of Critical Care, Abe and colleagues report results of a retrospective study that show a significantly higher incidence of Gram-negative bacteremia among adult intensive care unit patients with sep...

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated myocardial inflammation and subsequent cardiac contractile dysfunction. Sepsis was produced in adult male Sprague-Dawley rats via intratracheal injection of S. pneumonia (4 × 10(6) colony formation units per rat). A single...

Objective To evaluate the adequacy of serum C-reactive protein (CRP) in diagnosing neonatal sepsis and role of CRP in determining the duration of antibiotic treatment in neonatal sepsis. Methods In this validation study, we included 135 neonates with suspected diagnosis of sepsis within duration of nine months from September 2016 to May2017 in Children Hospital Multan. Blood samples were draw...

C reactive protein (CRP) concentrations are used routinely in the investigation and monitoring of neonatal sepsis. In this study, CRP responses were examined in the first week after birth. Among infants showing a clinically relevant CRP response, CRP concentrations > 60 mg/l were more likely with increasing gestational age.