The article by Mogadam et al. (1) regarding the comparison of analgesic effect of gabapentin and diclofenac on pain after tonsillectomy was interesting, as it explained the comparison of analgesic efficacy results of preoperative gabapentin and diclofenac administration on postoperative pain in tonsillectomy. However, it is noted that one of the main factors which influences the rate of drug ab...

Background and aims: Corticotropin releasing hormone (CRH) is a major mediator of the stress response in the brain-gut axis. Irritable bowel syndrome (IBS) is presumed to be a disorder of the brain-gut link associated with an exaggerated response to stress. We hypothesised that peripheral administration of a-helical CRH (ahCRH), a non-selective CRH receptor antagonist, would improve gastrointes...

BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...

PURPOSE In this study, we retrospectively investigated case reports with and without midazolam administration via oral, intranasal and rectal before cystometry procedure. We aimed to compare the data to evaluate the effects of sedation before cystometry on the pediatric patients and parents' satisfaction. METHODS A total of 124 ASA I-II pediatric cases aged 5-14 years were retrospectively inv...

PURPOSE The concentration of capecitabine peaks at 1-2 hours after administration. We therefore assumed that proper timing of capecitabine administration and radiotherapy would maximize radiosensitization and influence survival among patients with locally advanced rectal cancer. MATERIALS AND METHODS We retrospectively reviewed 223 patients with locally advanced rectal cancer who underwent pr...

The complex unfolding of the US opioid epidemic in last 20 years has been subject a large body medical and pharmacological research, it sparked multidisciplinary discussion on how to implement interventions policies effectively control its impact public health. This study leverages Reddit as primary data source investigate crisis. We aimed find cohort users interested discussing use opioids, tr...

OBJECTIVE To describe a patient with reversible posterior leukoencephalopathy syndrome following the administration of bevacizumab (Avastin), a monoclonal antibody against vascular endothelial growth factor. DESIGN Case report/literature review. SETTING University hospital. PATIENT A 52-year-old man receiving chemotherapy for stage IV rectal carcinoma. RESULTS Clinical and radiographic ...

OBJECTIVES a) To compare the clinical effect of rectal misoprostol with intramuscular syntometrine in reducing blood loss in the third stage of labour b) to determine the severity and incidence of side effects of both drugs and c) to measure blood loss, patient tolerance and acceptance of rectal misoprostol. METHODS One hundred and forty parturients were randomly allocated to receive intramus...

Objective To evaluate efficacy and safety of rectal form of ibuprofen and comparing to indomethacin for treatment of patent ductus arteriosus (PDA) in premature neonates. Methods Single-center, cohort, prospective study without prerandomization was performed in 38 preterm infants at gestational age 25-31 weeks were treated in NICU of Dnepropetrovsk Regional Children's Hospital (Ukraine) during ...