Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive which occurs before the 20th weeks of pregnancies for last menstrual period. Hereditary cause thrombophilic gene mutations and polymorphism may play an essential role in RPLs. Material Method: 291 women with a history abortions study group 61 without miscarriages control were included study. In this we analysed e...

OBJECTIVE MicroRNAs (miRNAs) regulate gene expression during the peri-implantation period. The purpose of this study was to investigate whether genetic polymorphisms in the four miRNAs associated with fetal or placental development play roles in the development of idiopathic recurrent pregnancy loss (RPL) in Korean females. STUDY DESIGN A case-control study involving 225 controls and 387 wome...

Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms,...

Antiphospholipid syndrome (APS), characterized by circulating antiphospholipid (aPL) antibodies, is a major cause of early pregnancy failure and placental insufficiency. In this study, we examined whether impaired endometrial differentiation before conception contributes to the high incidence of pregnancy complications in APS. Timed secretory endometrial biopsies were obtained from a cohort of ...

recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. it has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. thrombophilia is an important predisposition to blood clot formation and is cons...

Aim and Objective: Investigating for pregnancy loss is usually recommended only after two or more losses. But women with single seek explanation, in practice. This study conducted order to determine the identifiable causes their proportion early compare that of recurrent (RPL). Materials Methods: cross-sectional analytical undertaken between January 2021 2022. Group A included 50 B RPL. The inv...

We assessed the predictive ability of a combined genetic variant panel for risk recurrent pregnancy loss (RPL) through case-control study. Our study sample was from Ukraine and included 114 cases with idiopathic RPL 106 controls without any losses/complications at least one healthy child. genotyped variants within 12 loci reflecting main biological pathways involved in maintenance: blood coagul...

BACKGROUND Progesterone is a key hormonal regulator of the female reproductive system. It plays a major role to prepare the uterus for implantation and in the establishment and maintenance of pregnancy. Actions of progesterone on the uterine tissues (endometrium, myometrium and cervix) are mediated by the combined effects of two progesterone receptor (PR) isoforms, designated PR-A and PR-B. Bot...